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PrimPol—A new polymerase on the block

The DNA-directed primase-polymerase PrimPol of the archaeo-eukaryotic primase superfamily represents an ancient solution to the many problems faced during genome duplication. This versatile enzyme is capable of initiating de novo DNA/RNA synthesis, DNA chain elongation, and has the capacity to bypas...

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Detalles Bibliográficos
Autores principales: Rudd, Sean G, Bianchi, Julie, Doherty, Aidan J
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4905188/
https://www.ncbi.nlm.nih.gov/pubmed/27308331
http://dx.doi.org/10.4161/23723548.2014.960754
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author Rudd, Sean G
Bianchi, Julie
Doherty, Aidan J
author_facet Rudd, Sean G
Bianchi, Julie
Doherty, Aidan J
author_sort Rudd, Sean G
collection PubMed
description The DNA-directed primase-polymerase PrimPol of the archaeo-eukaryotic primase superfamily represents an ancient solution to the many problems faced during genome duplication. This versatile enzyme is capable of initiating de novo DNA/RNA synthesis, DNA chain elongation, and has the capacity to bypass modifications that stall the replisome by trans-lesion synthesis or origin-independent re-priming, thus allowing discontinuous synthesis of the leading strand. Recent studies have shown that PrimPol is an important new player in replication fork progression in eukaryotic cells; this review summarizes our current understanding of PrimPol and highlights important questions that remain to be addressed.
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spelling pubmed-49051882016-06-15 PrimPol—A new polymerase on the block Rudd, Sean G Bianchi, Julie Doherty, Aidan J Mol Cell Oncol Review The DNA-directed primase-polymerase PrimPol of the archaeo-eukaryotic primase superfamily represents an ancient solution to the many problems faced during genome duplication. This versatile enzyme is capable of initiating de novo DNA/RNA synthesis, DNA chain elongation, and has the capacity to bypass modifications that stall the replisome by trans-lesion synthesis or origin-independent re-priming, thus allowing discontinuous synthesis of the leading strand. Recent studies have shown that PrimPol is an important new player in replication fork progression in eukaryotic cells; this review summarizes our current understanding of PrimPol and highlights important questions that remain to be addressed. Taylor & Francis 2014-10-29 /pmc/articles/PMC4905188/ /pubmed/27308331 http://dx.doi.org/10.4161/23723548.2014.960754 Text en © 2014 The Author(s). 2014 Taylor & Francis Group, LLC http://creativecommons.org/licenses/by-nc/3.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution-Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/), which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. The moral rights of the named author(s) have been asserted.
spellingShingle Review
Rudd, Sean G
Bianchi, Julie
Doherty, Aidan J
PrimPol—A new polymerase on the block
title PrimPol—A new polymerase on the block
title_full PrimPol—A new polymerase on the block
title_fullStr PrimPol—A new polymerase on the block
title_full_unstemmed PrimPol—A new polymerase on the block
title_short PrimPol—A new polymerase on the block
title_sort primpol—a new polymerase on the block
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4905188/
https://www.ncbi.nlm.nih.gov/pubmed/27308331
http://dx.doi.org/10.4161/23723548.2014.960754
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