SIN3B, the SASP, and pancreatic cancer

Cellular senescence is classically considered a tumor suppressive mechanism. In addition to having stably exited the cell cycle, senescent cells secrete inflammatory factors. We recently demonstrated that senescence correlates with accelerated cancer progression in a mouse model of pancreatic ductal...

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Detalles Bibliográficos
Autores principales: Cantor, David J, David, Gregory
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2014
Materias:
Author's View
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4905214/
https://www.ncbi.nlm.nih.gov/pubmed/27308374
http://dx.doi.org/10.4161/23723548.2014.969167
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author Cantor, David J
David, Gregory
author_facet Cantor, David J
David, Gregory
author_sort Cantor, David J
collection PubMed
description Cellular senescence is classically considered a tumor suppressive mechanism. In addition to having stably exited the cell cycle, senescent cells secrete inflammatory factors. We recently demonstrated that senescence correlates with accelerated cancer progression in a mouse model of pancreatic ductal adenocarcinoma. Here, we discuss the implications of this study.
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spelling pubmed-49052142016-06-15 SIN3B, the SASP, and pancreatic cancer Cantor, David J David, Gregory Mol Cell Oncol Author's View Cellular senescence is classically considered a tumor suppressive mechanism. In addition to having stably exited the cell cycle, senescent cells secrete inflammatory factors. We recently demonstrated that senescence correlates with accelerated cancer progression in a mouse model of pancreatic ductal adenocarcinoma. Here, we discuss the implications of this study. Taylor & Francis 2014-11-11 /pmc/articles/PMC4905214/ /pubmed/27308374 http://dx.doi.org/10.4161/23723548.2014.969167 Text en © 2014 The Author(s). Published with license by Taylor & Francis Group, LLC http://creativecommons.org/licenses/by-nc/3.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution-Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/), which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. The moral rights of the named author(s) have been asserted.
spellingShingle Author's View
Cantor, David J
David, Gregory
SIN3B, the SASP, and pancreatic cancer
title SIN3B, the SASP, and pancreatic cancer
title_full SIN3B, the SASP, and pancreatic cancer
title_fullStr SIN3B, the SASP, and pancreatic cancer
title_full_unstemmed SIN3B, the SASP, and pancreatic cancer
title_short SIN3B, the SASP, and pancreatic cancer
title_sort sin3b, the sasp, and pancreatic cancer
topic Author's View
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4905214/
https://www.ncbi.nlm.nih.gov/pubmed/27308374
http://dx.doi.org/10.4161/23723548.2014.969167
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