Cytosolic pH: A conserved regulator of cell growth?

Although target of rapamycin (TOR) kinase and Ras are central regulators of cell growth in yeast and mammals, the molecular mechanisms underlying their regulation by nutrients are still poorly understood. Interestingly, recent studies identified cytosolic pH as a critical regulatory signal for both...

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Detalles Bibliográficos
Autores principales: Dechant, Reinhard, Peter, Matthias
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2014
Materias:
Author's View
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4905219/
https://www.ncbi.nlm.nih.gov/pubmed/27308377
http://dx.doi.org/10.4161/23723548.2014.969643
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author Dechant, Reinhard
Peter, Matthias
author_facet Dechant, Reinhard
Peter, Matthias
author_sort Dechant, Reinhard
collection PubMed
description Although target of rapamycin (TOR) kinase and Ras are central regulators of cell growth in yeast and mammals, the molecular mechanisms underlying their regulation by nutrients are still poorly understood. Interestingly, recent studies identified cytosolic pH as a critical regulatory signal for both pathways, which might have widespread implications for tumor cell biology
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spelling pubmed-49052192016-06-15 Cytosolic pH: A conserved regulator of cell growth? Dechant, Reinhard Peter, Matthias Mol Cell Oncol Author's View Although target of rapamycin (TOR) kinase and Ras are central regulators of cell growth in yeast and mammals, the molecular mechanisms underlying their regulation by nutrients are still poorly understood. Interestingly, recent studies identified cytosolic pH as a critical regulatory signal for both pathways, which might have widespread implications for tumor cell biology Taylor & Francis 2014-12-31 /pmc/articles/PMC4905219/ /pubmed/27308377 http://dx.doi.org/10.4161/23723548.2014.969643 Text en © 2014 The Author(s). Published with license by Taylor & Francis Group, LLC http://creativecommons.org/licenses/by-nc/3.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution-Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/), which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. The moral rights of the named author(s) have been asserted.
spellingShingle Author's View
Dechant, Reinhard
Peter, Matthias
Cytosolic pH: A conserved regulator of cell growth?
title Cytosolic pH: A conserved regulator of cell growth?
title_full Cytosolic pH: A conserved regulator of cell growth?
title_fullStr Cytosolic pH: A conserved regulator of cell growth?
title_full_unstemmed Cytosolic pH: A conserved regulator of cell growth?
title_short Cytosolic pH: A conserved regulator of cell growth?
title_sort cytosolic ph: a conserved regulator of cell growth?
topic Author's View
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4905219/
https://www.ncbi.nlm.nih.gov/pubmed/27308377
http://dx.doi.org/10.4161/23723548.2014.969643
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