Pro-survival role of p62 during granulocytic differentiation of acute myeloid leukemia cells

p62 regulates key signaling pathways including those that control cell death and autophagy. Recently, we reported that p62 is upregulated during all-trans retinoic acid (ATRA)-induced terminal differentiation of acute myeloid leukemia (AML) cells. This response reduces levels of ubiquitinated protei...

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Autores principales: Ségal-Bendirdjian, Evelyne, Tschan, Mario P, Reiffers, Josy, Djavaheri-Mergny, Mojgan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2014
Materias:
Author's View
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4905221/
https://www.ncbi.nlm.nih.gov/pubmed/27308379
http://dx.doi.org/10.4161/23723548.2014.970066
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author Ségal-Bendirdjian, Evelyne
Tschan, Mario P
Reiffers, Josy
Djavaheri-Mergny, Mojgan
author_facet Ségal-Bendirdjian, Evelyne
Tschan, Mario P
Reiffers, Josy
Djavaheri-Mergny, Mojgan
author_sort Ségal-Bendirdjian, Evelyne
collection PubMed
description p62 regulates key signaling pathways including those that control cell death and autophagy. Recently, we reported that p62 is upregulated during all-trans retinoic acid (ATRA)-induced terminal differentiation of acute myeloid leukemia (AML) cells. This response reduces levels of ubiquitinated protein aggregates in mature cells and protects these cells against ATRA treatment. Thus, p62 confers a survival advantage to mature AML cells.
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spelling pubmed-49052212016-06-15 Pro-survival role of p62 during granulocytic differentiation of acute myeloid leukemia cells Ségal-Bendirdjian, Evelyne Tschan, Mario P Reiffers, Josy Djavaheri-Mergny, Mojgan Mol Cell Oncol Author's View p62 regulates key signaling pathways including those that control cell death and autophagy. Recently, we reported that p62 is upregulated during all-trans retinoic acid (ATRA)-induced terminal differentiation of acute myeloid leukemia (AML) cells. This response reduces levels of ubiquitinated protein aggregates in mature cells and protects these cells against ATRA treatment. Thus, p62 confers a survival advantage to mature AML cells. Taylor & Francis 2014-12-31 /pmc/articles/PMC4905221/ /pubmed/27308379 http://dx.doi.org/10.4161/23723548.2014.970066 Text en © 2014 The Author(s). Published with license by Taylor & Francis Group, LLC http://creativecommons.org/licenses/by-nc/3.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution-Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/), which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. The moral rights of the named author(s) have been asserted.
spellingShingle Author's View
Ségal-Bendirdjian, Evelyne
Tschan, Mario P
Reiffers, Josy
Djavaheri-Mergny, Mojgan
Pro-survival role of p62 during granulocytic differentiation of acute myeloid leukemia cells
title Pro-survival role of p62 during granulocytic differentiation of acute myeloid leukemia cells
title_full Pro-survival role of p62 during granulocytic differentiation of acute myeloid leukemia cells
title_fullStr Pro-survival role of p62 during granulocytic differentiation of acute myeloid leukemia cells
title_full_unstemmed Pro-survival role of p62 during granulocytic differentiation of acute myeloid leukemia cells
title_short Pro-survival role of p62 during granulocytic differentiation of acute myeloid leukemia cells
title_sort pro-survival role of p62 during granulocytic differentiation of acute myeloid leukemia cells
topic Author's View
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4905221/
https://www.ncbi.nlm.nih.gov/pubmed/27308379
http://dx.doi.org/10.4161/23723548.2014.970066
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