Sonic Hedgehog factor Gli1: As good as resistant

Chemoresistance remains a major impediment in cancer therapy. Although major progress has been made in understanding the mechanisms underlying resistance in cancer, there is still more to learn. Our studies provide evidence that Gli1 drives a novel form of drug resistance involving Phase II drug met...

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Detalles Bibliográficos
Autores principales: Zahreddine, Hiba Ahmad, Culjkovic-Kraljacic, Biljana, Borden, Katherine LB
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2015
Materias:
Author's View
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4905224/
https://www.ncbi.nlm.nih.gov/pubmed/27308395
http://dx.doi.org/10.4161/23723548.2014.961827
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author Zahreddine, Hiba Ahmad
Culjkovic-Kraljacic, Biljana
Borden, Katherine LB
author_facet Zahreddine, Hiba Ahmad
Culjkovic-Kraljacic, Biljana
Borden, Katherine LB
author_sort Zahreddine, Hiba Ahmad
collection PubMed
description Chemoresistance remains a major impediment in cancer therapy. Although major progress has been made in understanding the mechanisms underlying resistance in cancer, there is still more to learn. Our studies provide evidence that Gli1 drives a novel form of drug resistance involving Phase II drug metabolism enzymes, specifically the UGT1A family.
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spelling pubmed-49052242016-06-15 Sonic Hedgehog factor Gli1: As good as resistant Zahreddine, Hiba Ahmad Culjkovic-Kraljacic, Biljana Borden, Katherine LB Mol Cell Oncol Author's View Chemoresistance remains a major impediment in cancer therapy. Although major progress has been made in understanding the mechanisms underlying resistance in cancer, there is still more to learn. Our studies provide evidence that Gli1 drives a novel form of drug resistance involving Phase II drug metabolism enzymes, specifically the UGT1A family. Taylor & Francis 2015-02-24 /pmc/articles/PMC4905224/ /pubmed/27308395 http://dx.doi.org/10.4161/23723548.2014.961827 Text en © 2015 The Author(s). Published with license by Taylor & Francis Group, LLC http://creativecommons.org/licenses/by-nc/3.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution-Non-Commercial License http://creativecommons.org/licenses/by-nc/3.0/, which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. The moral rights of the named author(s) have been asserted.
spellingShingle Author's View
Zahreddine, Hiba Ahmad
Culjkovic-Kraljacic, Biljana
Borden, Katherine LB
Sonic Hedgehog factor Gli1: As good as resistant
title Sonic Hedgehog factor Gli1: As good as resistant
title_full Sonic Hedgehog factor Gli1: As good as resistant
title_fullStr Sonic Hedgehog factor Gli1: As good as resistant
title_full_unstemmed Sonic Hedgehog factor Gli1: As good as resistant
title_short Sonic Hedgehog factor Gli1: As good as resistant
title_sort sonic hedgehog factor gli1: as good as resistant
topic Author's View
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4905224/
https://www.ncbi.nlm.nih.gov/pubmed/27308395
http://dx.doi.org/10.4161/23723548.2014.961827
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