XIAP as a regulator of inflammatory cell death: the TNF and RIP3 angle

There is currently immense interest in understanding the biological consequences of aberrant necroptosis. The recently uncovered role for X-linked inhibitor of apoptosis protein (XIAP) in blocking tumor necrosis factor-dependent necroptosis explains, at least in part, the systemic hyperinflammatory...

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Detalles Bibliográficos
Autores principales: Yabal, Monica, Jost, Philipp J
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2014
Materias:
Author's View
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4905225/
https://www.ncbi.nlm.nih.gov/pubmed/27308382
http://dx.doi.org/10.4161/23723548.2014.964622
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author Yabal, Monica
Jost, Philipp J
author_facet Yabal, Monica
Jost, Philipp J
author_sort Yabal, Monica
collection PubMed
description There is currently immense interest in understanding the biological consequences of aberrant necroptosis. The recently uncovered role for X-linked inhibitor of apoptosis protein (XIAP) in blocking tumor necrosis factor-dependent necroptosis explains, at least in part, the systemic hyperinflammatory syndrome XLP-2. However, it also points to rather unexpected differences between XIAP and the related proteins baculoviral IAP repeat containing 2 and 3 (cIAP1/2).
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spelling pubmed-49052252016-06-15 XIAP as a regulator of inflammatory cell death: the TNF and RIP3 angle Yabal, Monica Jost, Philipp J Mol Cell Oncol Author's View There is currently immense interest in understanding the biological consequences of aberrant necroptosis. The recently uncovered role for X-linked inhibitor of apoptosis protein (XIAP) in blocking tumor necrosis factor-dependent necroptosis explains, at least in part, the systemic hyperinflammatory syndrome XLP-2. However, it also points to rather unexpected differences between XIAP and the related proteins baculoviral IAP repeat containing 2 and 3 (cIAP1/2). Taylor & Francis 2014-10-29 /pmc/articles/PMC4905225/ /pubmed/27308382 http://dx.doi.org/10.4161/23723548.2014.964622 Text en © 2015 The Author(s). Published with license by Taylor & Francis Group, LLC http://creativecommons.org/licenses/by-nc/3.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution-Non-Commercial License http://creativecommons.org/licenses/by-nc/3.0/, which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. The moral rights of the named author(s) have been asserted.
spellingShingle Author's View
Yabal, Monica
Jost, Philipp J
XIAP as a regulator of inflammatory cell death: the TNF and RIP3 angle
title XIAP as a regulator of inflammatory cell death: the TNF and RIP3 angle
title_full XIAP as a regulator of inflammatory cell death: the TNF and RIP3 angle
title_fullStr XIAP as a regulator of inflammatory cell death: the TNF and RIP3 angle
title_full_unstemmed XIAP as a regulator of inflammatory cell death: the TNF and RIP3 angle
title_short XIAP as a regulator of inflammatory cell death: the TNF and RIP3 angle
title_sort xiap as a regulator of inflammatory cell death: the tnf and rip3 angle
topic Author's View
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4905225/
https://www.ncbi.nlm.nih.gov/pubmed/27308382
http://dx.doi.org/10.4161/23723548.2014.964622
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AT jostphilippj xiapasaregulatorofinflammatorycelldeaththetnfandrip3angle

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