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Role of the double-strand break repair pathway in the maintenance of genomic stability

DNA double-strand breaks (DSBs) are highly lethal lesions that jeopardize genome integrity. However, DSBs are also used to generate diversity during the physiological processes of meiosis or establishment of the immune repertoire. Therefore, DSB repair must be tightly controlled. Two main strategies...

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Detalles Bibliográficos
Autores principales:	Le Guen, Tangui, Ragu, Sandrine, Guirouilh-Barbat, Josée, Lopez, Bernard S
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Taylor & Francis 2014
Materias:	Review
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4905226/ https://www.ncbi.nlm.nih.gov/pubmed/27308383 http://dx.doi.org/10.4161/23723548.2014.968020

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