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Imatinib may be ABL to improve anti-angiogenic therapy

We recently reported that neuropilin 1 (NRP1) drives angiogenesis by promoting extracellular matrix signaling in endothelial cells via ABL1 kinase. Imatinib targets this pathway in pathological angiogenesis and may provide a novel opportunity for anti-angiogenic therapy of age-related macular degene...

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Detalles Bibliográficos
Autores principales: Raimondi, Claudio, Fantin, Alessandro, Ruhrberg, Christiana
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4905228/
https://www.ncbi.nlm.nih.gov/pubmed/27308396
http://dx.doi.org/10.4161/23723548.2014.968034

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