The secret life of quiescent cancer stem cells

Quiescence represents a survival strategy adopted by cancer stem cells (CSCs) to resist harsh environmental conditions and cytotoxic insults. Recent studies show that quiescent CSCs are found in a low metabolic state in which they are exquisitely dependent on Bcl-2 or Bcl-XL, indicating new potentia...

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Detalles Bibliográficos
Autor principal: Zeuner, Ann
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2014
Materias:
Commentary
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4905231/
https://www.ncbi.nlm.nih.gov/pubmed/27308385
http://dx.doi.org/10.4161/23723548.2014.968067
Descripción
Sumario:Quiescence represents a survival strategy adopted by cancer stem cells (CSCs) to resist harsh environmental conditions and cytotoxic insults. Recent studies show that quiescent CSCs are found in a low metabolic state in which they are exquisitely dependent on Bcl-2 or Bcl-XL, indicating new potential routes of clinical intervention.

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