The secret life of quiescent cancer stem cells

Quiescence represents a survival strategy adopted by cancer stem cells (CSCs) to resist harsh environmental conditions and cytotoxic insults. Recent studies show that quiescent CSCs are found in a low metabolic state in which they are exquisitely dependent on Bcl-2 or Bcl-XL, indicating new potentia...

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Detalles Bibliográficos
Autor principal: Zeuner, Ann
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2014
Materias:
Commentary
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4905231/
https://www.ncbi.nlm.nih.gov/pubmed/27308385
http://dx.doi.org/10.4161/23723548.2014.968067
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author Zeuner, Ann
author_facet Zeuner, Ann
author_sort Zeuner, Ann
collection PubMed
description Quiescence represents a survival strategy adopted by cancer stem cells (CSCs) to resist harsh environmental conditions and cytotoxic insults. Recent studies show that quiescent CSCs are found in a low metabolic state in which they are exquisitely dependent on Bcl-2 or Bcl-XL, indicating new potential routes of clinical intervention.
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spelling pubmed-49052312016-06-15 The secret life of quiescent cancer stem cells Zeuner, Ann Mol Cell Oncol Commentary Quiescence represents a survival strategy adopted by cancer stem cells (CSCs) to resist harsh environmental conditions and cytotoxic insults. Recent studies show that quiescent CSCs are found in a low metabolic state in which they are exquisitely dependent on Bcl-2 or Bcl-XL, indicating new potential routes of clinical intervention. Taylor & Francis 2014-10-30 /pmc/articles/PMC4905231/ /pubmed/27308385 http://dx.doi.org/10.4161/23723548.2014.968067 Text en © 2015 The Author(s). Published with license by Taylor & Francis Group, LLC http://creativecommons.org/licenses/by-nc/3.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution-Non-Commercial License http://creativecommons.org/licenses/by-nc/3.0/, which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. The moral rights of the named author(s) have been asserted.
spellingShingle Commentary
Zeuner, Ann
The secret life of quiescent cancer stem cells
title The secret life of quiescent cancer stem cells
title_full The secret life of quiescent cancer stem cells
title_fullStr The secret life of quiescent cancer stem cells
title_full_unstemmed The secret life of quiescent cancer stem cells
title_short The secret life of quiescent cancer stem cells
title_sort secret life of quiescent cancer stem cells
topic Commentary
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4905231/
https://www.ncbi.nlm.nih.gov/pubmed/27308385
http://dx.doi.org/10.4161/23723548.2014.968067
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