Molecular mechanisms involved in initiation of the DNA damage response

DNA is subject to a wide variety of damage. In order to maintain genomic integrity, cells must respond to this damage by activating repair and cell cycle checkpoint pathways. The initiating events in the DNA damage response entail recognition of the lesion and the assembly of DNA damage response com...

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Detalles Bibliográficos
Autores principales: Barnum, Kevin J, O’Connell, Matthew J
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2015
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4905235/
https://www.ncbi.nlm.nih.gov/pubmed/27308403
http://dx.doi.org/10.4161/23723548.2014.970065
Descripción
Sumario:DNA is subject to a wide variety of damage. In order to maintain genomic integrity, cells must respond to this damage by activating repair and cell cycle checkpoint pathways. The initiating events in the DNA damage response entail recognition of the lesion and the assembly of DNA damage response complexes at the DNA. Here, we review what is known about these processes for various DNA damage pathways.

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