Molecular mechanisms involved in initiation of the DNA damage response

DNA is subject to a wide variety of damage. In order to maintain genomic integrity, cells must respond to this damage by activating repair and cell cycle checkpoint pathways. The initiating events in the DNA damage response entail recognition of the lesion and the assembly of DNA damage response com...

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Detalles Bibliográficos
Autores principales: Barnum, Kevin J, O’Connell, Matthew J
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2015
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4905235/
https://www.ncbi.nlm.nih.gov/pubmed/27308403
http://dx.doi.org/10.4161/23723548.2014.970065
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author Barnum, Kevin J
O’Connell, Matthew J
author_facet Barnum, Kevin J
O’Connell, Matthew J
author_sort Barnum, Kevin J
collection PubMed
description DNA is subject to a wide variety of damage. In order to maintain genomic integrity, cells must respond to this damage by activating repair and cell cycle checkpoint pathways. The initiating events in the DNA damage response entail recognition of the lesion and the assembly of DNA damage response complexes at the DNA. Here, we review what is known about these processes for various DNA damage pathways.
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spelling pubmed-49052352016-06-15 Molecular mechanisms involved in initiation of the DNA damage response Barnum, Kevin J O’Connell, Matthew J Mol Cell Oncol Review DNA is subject to a wide variety of damage. In order to maintain genomic integrity, cells must respond to this damage by activating repair and cell cycle checkpoint pathways. The initiating events in the DNA damage response entail recognition of the lesion and the assembly of DNA damage response complexes at the DNA. Here, we review what is known about these processes for various DNA damage pathways. Taylor & Francis 2015-01-23 /pmc/articles/PMC4905235/ /pubmed/27308403 http://dx.doi.org/10.4161/23723548.2014.970065 Text en © 2015 The Author(s). Published with license by Taylor & Francis Group, LLC http://creativecommons.org/licenses/by-nc/3.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution-Non-Commercial License http://creativecommons.org/licenses/by-nc/3.0/, which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. The moral rights of the named author(s) have been asserted.
spellingShingle Review
Barnum, Kevin J
O’Connell, Matthew J
Molecular mechanisms involved in initiation of the DNA damage response
title Molecular mechanisms involved in initiation of the DNA damage response
title_full Molecular mechanisms involved in initiation of the DNA damage response
title_fullStr Molecular mechanisms involved in initiation of the DNA damage response
title_full_unstemmed Molecular mechanisms involved in initiation of the DNA damage response
title_short Molecular mechanisms involved in initiation of the DNA damage response
title_sort molecular mechanisms involved in initiation of the dna damage response
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4905235/
https://www.ncbi.nlm.nih.gov/pubmed/27308403
http://dx.doi.org/10.4161/23723548.2014.970065
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