The PBAF chromatin remodeling complex represses transcription and promotes rapid repair at DNA double-strand breaks

Transcription in the vicinity of DNA double-strand breaks (DSBs) is suppressed via a process involving ataxia telangiectasia mutated protein (ATM) and H2AK119 ubiquitylation.(1) We discuss recent findings that components of the Polybromo and Brahma-related gene 1 (BRG1)-associated factor (PBAF) remo...

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Autores principales: Kakarougkas, Andreas, Downs, Jessica A, Jeggo, Penny A
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2015
Materias:
Author's View
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4905236/
https://www.ncbi.nlm.nih.gov/pubmed/27308404
http://dx.doi.org/10.4161/23723548.2014.970072
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author Kakarougkas, Andreas
Downs, Jessica A
Jeggo, Penny A
author_facet Kakarougkas, Andreas
Downs, Jessica A
Jeggo, Penny A
author_sort Kakarougkas, Andreas
collection PubMed
description Transcription in the vicinity of DNA double-strand breaks (DSBs) is suppressed via a process involving ataxia telangiectasia mutated protein (ATM) and H2AK119 ubiquitylation.(1) We discuss recent findings that components of the Polybromo and Brahma-related gene 1 (BRG1)-associated factor (PBAF) remodeling complex and the polycomb repressive complex (PRC1/2) are also required.(2) Failure to activate transcriptional suppression impedes a rapid DSB repair process.
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spelling pubmed-49052362016-06-15 The PBAF chromatin remodeling complex represses transcription and promotes rapid repair at DNA double-strand breaks Kakarougkas, Andreas Downs, Jessica A Jeggo, Penny A Mol Cell Oncol Author's View Transcription in the vicinity of DNA double-strand breaks (DSBs) is suppressed via a process involving ataxia telangiectasia mutated protein (ATM) and H2AK119 ubiquitylation.(1) We discuss recent findings that components of the Polybromo and Brahma-related gene 1 (BRG1)-associated factor (PBAF) remodeling complex and the polycomb repressive complex (PRC1/2) are also required.(2) Failure to activate transcriptional suppression impedes a rapid DSB repair process. Taylor & Francis 2015-01-23 /pmc/articles/PMC4905236/ /pubmed/27308404 http://dx.doi.org/10.4161/23723548.2014.970072 Text en © 2015 The Author(s). Published with license by Taylor & Francis Group, LLC http://creativecommons.org/licenses/by-nc/3.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution-Non-Commercial License http://creativecommons.org/licenses/by-nc/3.0/, which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. The moral rights of the named author(s) have been asserted.
spellingShingle Author's View
Kakarougkas, Andreas
Downs, Jessica A
Jeggo, Penny A
The PBAF chromatin remodeling complex represses transcription and promotes rapid repair at DNA double-strand breaks
title The PBAF chromatin remodeling complex represses transcription and promotes rapid repair at DNA double-strand breaks
title_full The PBAF chromatin remodeling complex represses transcription and promotes rapid repair at DNA double-strand breaks
title_fullStr The PBAF chromatin remodeling complex represses transcription and promotes rapid repair at DNA double-strand breaks
title_full_unstemmed The PBAF chromatin remodeling complex represses transcription and promotes rapid repair at DNA double-strand breaks
title_short The PBAF chromatin remodeling complex represses transcription and promotes rapid repair at DNA double-strand breaks
title_sort pbaf chromatin remodeling complex represses transcription and promotes rapid repair at dna double-strand breaks
topic Author's View
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4905236/
https://www.ncbi.nlm.nih.gov/pubmed/27308404
http://dx.doi.org/10.4161/23723548.2014.970072
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