Conditional haploinsufficiency of the retinoblastoma tumor suppressor gene

Recent work demonstrates that retention of a single functional retinoblastoma susceptibility (RB1) allele is insufficient to maintain genome stability. Haploinsufficiency of RB1 accelerates cancer pathogenesis in concert with inactivation of tumor protein p53. Collectively, multiple lines of evidenc...

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Detalles Bibliográficos
Autores principales: Ishak, Charles A, Dick, Frederick A
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2014
Materias:
Author's View
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4905237/
https://www.ncbi.nlm.nih.gov/pubmed/27308386
http://dx.doi.org/10.4161/23723548.2014.968069
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author Ishak, Charles A
Dick, Frederick A
author_facet Ishak, Charles A
Dick, Frederick A
author_sort Ishak, Charles A
collection PubMed
description Recent work demonstrates that retention of a single functional retinoblastoma susceptibility (RB1) allele is insufficient to maintain genome stability. Haploinsufficiency of RB1 accelerates cancer pathogenesis in concert with inactivation of tumor protein p53. Collectively, multiple lines of evidence suggest revision of the ‘2-hit’ model to include conditional haploinsufficiency of RB1.
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spelling pubmed-49052372016-06-15 Conditional haploinsufficiency of the retinoblastoma tumor suppressor gene Ishak, Charles A Dick, Frederick A Mol Cell Oncol Author's View Recent work demonstrates that retention of a single functional retinoblastoma susceptibility (RB1) allele is insufficient to maintain genome stability. Haploinsufficiency of RB1 accelerates cancer pathogenesis in concert with inactivation of tumor protein p53. Collectively, multiple lines of evidence suggest revision of the ‘2-hit’ model to include conditional haploinsufficiency of RB1. Taylor & Francis 2014-10-30 /pmc/articles/PMC4905237/ /pubmed/27308386 http://dx.doi.org/10.4161/23723548.2014.968069 Text en © 2015 The Author(s). Published with license by Taylor & Francis Group, LLC http://creativecommons.org/licenses/by-nc/3.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution-Non-Commercial License http://creativecommons.org/licenses/by-nc/3.0/, which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. The moral rights of the named author(s) have been asserted.
spellingShingle Author's View
Ishak, Charles A
Dick, Frederick A
Conditional haploinsufficiency of the retinoblastoma tumor suppressor gene
title Conditional haploinsufficiency of the retinoblastoma tumor suppressor gene
title_full Conditional haploinsufficiency of the retinoblastoma tumor suppressor gene
title_fullStr Conditional haploinsufficiency of the retinoblastoma tumor suppressor gene
title_full_unstemmed Conditional haploinsufficiency of the retinoblastoma tumor suppressor gene
title_short Conditional haploinsufficiency of the retinoblastoma tumor suppressor gene
title_sort conditional haploinsufficiency of the retinoblastoma tumor suppressor gene
topic Author's View
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4905237/
https://www.ncbi.nlm.nih.gov/pubmed/27308386
http://dx.doi.org/10.4161/23723548.2014.968069
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AT dickfredericka conditionalhaploinsufficiencyoftheretinoblastomatumorsuppressorgene

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