Nfkb1 suppresses DNA alkylation-induced tumor formation

NF-κB proteins play a complex role in modulating carcinogenesis following DNA damage. Previous work identified p50/NF-κB1 as a necessary factor in the cytotoxic response to alkylation damage. Recently, these findings were extended to demonstrate that in the setting of alkylation damage, this NF-κB s...

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Detalles Bibliográficos
Autores principales: Schmitt, Adam M, Yamini, Bakhtiar
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2015
Materias:
Author's View
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4905238/
https://www.ncbi.nlm.nih.gov/pubmed/27308399
http://dx.doi.org/10.4161/23723548.2014.968073
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author Schmitt, Adam M
Yamini, Bakhtiar
author_facet Schmitt, Adam M
Yamini, Bakhtiar
author_sort Schmitt, Adam M
collection PubMed
description NF-κB proteins play a complex role in modulating carcinogenesis following DNA damage. Previous work identified p50/NF-κB1 as a necessary factor in the cytotoxic response to alkylation damage. Recently, these findings were extended to demonstrate that in the setting of alkylation damage, this NF-κB subunit acts as a haploinsufficient tumor suppressor that prevents hematologic malignancy formation.
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spelling pubmed-49052382016-06-15 Nfkb1 suppresses DNA alkylation-induced tumor formation Schmitt, Adam M Yamini, Bakhtiar Mol Cell Oncol Author's View NF-κB proteins play a complex role in modulating carcinogenesis following DNA damage. Previous work identified p50/NF-κB1 as a necessary factor in the cytotoxic response to alkylation damage. Recently, these findings were extended to demonstrate that in the setting of alkylation damage, this NF-κB subunit acts as a haploinsufficient tumor suppressor that prevents hematologic malignancy formation. Taylor & Francis 2015-01-28 /pmc/articles/PMC4905238/ /pubmed/27308399 http://dx.doi.org/10.4161/23723548.2014.968073 Text en © 2015 The Author(s). Published with license by Taylor & Francis Group, LLC http://creativecommons.org/licenses/by-nc/3.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution-Non-Commercial License http://creativecommons.org/licenses/by-nc/3.0/, which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. The moral rights of the named author(s) have been asserted.
spellingShingle Author's View
Schmitt, Adam M
Yamini, Bakhtiar
Nfkb1 suppresses DNA alkylation-induced tumor formation
title Nfkb1 suppresses DNA alkylation-induced tumor formation
title_full Nfkb1 suppresses DNA alkylation-induced tumor formation
title_fullStr Nfkb1 suppresses DNA alkylation-induced tumor formation
title_full_unstemmed Nfkb1 suppresses DNA alkylation-induced tumor formation
title_short Nfkb1 suppresses DNA alkylation-induced tumor formation
title_sort nfkb1 suppresses dna alkylation-induced tumor formation
topic Author's View
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4905238/
https://www.ncbi.nlm.nih.gov/pubmed/27308399
http://dx.doi.org/10.4161/23723548.2014.968073
work_keys_str_mv AT schmittadamm nfkb1suppressesdnaalkylationinducedtumorformation
AT yaminibakhtiar nfkb1suppressesdnaalkylationinducedtumorformation

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