YAP inhibition blocks uveal melanogenesis driven by GNAQ or GNA11 mutations

Uveal melanoma (UM) is the most common adult intraocular tumor. UM often involves activating mutations in guanine nucleotide binding protein (G protein), q polypeptide (GQ), or G Protein, α 11 (G11). We show that the Yes-associated protein (Yap) inhibitor verteporfin blocks tumor growth of Gq/11-mut...

Descripción completa

Detalles Bibliográficos
Autores principales: Lyubasyuk, Vera, Ouyang, Hong, Yu, Fa-Xing, Guan, Kun-Liang, Zhang, Kang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2014
Materias:
Author's View
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4905245/
https://www.ncbi.nlm.nih.gov/pubmed/27308390
http://dx.doi.org/10.4161/23723548.2014.970957
_version_ 1782437235783630848
author Lyubasyuk, Vera
Ouyang, Hong
Yu, Fa-Xing
Guan, Kun-Liang
Zhang, Kang
author_facet Lyubasyuk, Vera
Ouyang, Hong
Yu, Fa-Xing
Guan, Kun-Liang
Zhang, Kang
author_sort Lyubasyuk, Vera
collection PubMed
description Uveal melanoma (UM) is the most common adult intraocular tumor. UM often involves activating mutations in guanine nucleotide binding protein (G protein), q polypeptide (GQ), or G Protein, α 11 (G11). We show that the Yes-associated protein (Yap) inhibitor verteporfin blocks tumor growth of Gq/11-mutated UM cells.
format Online
Article
Text
id pubmed-4905245
institution National Center for Biotechnology Information
language English
publishDate 2014
publisher Taylor & Francis
record_format MEDLINE/PubMed
spelling pubmed-49052452016-06-15 YAP inhibition blocks uveal melanogenesis driven by GNAQ or GNA11 mutations Lyubasyuk, Vera Ouyang, Hong Yu, Fa-Xing Guan, Kun-Liang Zhang, Kang Mol Cell Oncol Author's View Uveal melanoma (UM) is the most common adult intraocular tumor. UM often involves activating mutations in guanine nucleotide binding protein (G protein), q polypeptide (GQ), or G Protein, α 11 (G11). We show that the Yes-associated protein (Yap) inhibitor verteporfin blocks tumor growth of Gq/11-mutated UM cells. Taylor & Francis 2014-12-01 /pmc/articles/PMC4905245/ /pubmed/27308390 http://dx.doi.org/10.4161/23723548.2014.970957 Text en © 2015 The Author(s). Published with license by Taylor & Francis Group, LLC http://creativecommons.org/licenses/by-nc/3.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution-Non-Commercial License http://creativecommons.org/licenses/by-nc/3.0/, which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. The moral rights of the named author(s) have been asserted.
spellingShingle Author's View
Lyubasyuk, Vera
Ouyang, Hong
Yu, Fa-Xing
Guan, Kun-Liang
Zhang, Kang
YAP inhibition blocks uveal melanogenesis driven by GNAQ or GNA11 mutations
title YAP inhibition blocks uveal melanogenesis driven by GNAQ or GNA11 mutations
title_full YAP inhibition blocks uveal melanogenesis driven by GNAQ or GNA11 mutations
title_fullStr YAP inhibition blocks uveal melanogenesis driven by GNAQ or GNA11 mutations
title_full_unstemmed YAP inhibition blocks uveal melanogenesis driven by GNAQ or GNA11 mutations
title_short YAP inhibition blocks uveal melanogenesis driven by GNAQ or GNA11 mutations
title_sort yap inhibition blocks uveal melanogenesis driven by gnaq or gna11 mutations
topic Author's View
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4905245/
https://www.ncbi.nlm.nih.gov/pubmed/27308390
http://dx.doi.org/10.4161/23723548.2014.970957
work_keys_str_mv AT lyubasyukvera yapinhibitionblocksuvealmelanogenesisdrivenbygnaqorgna11mutations
AT ouyanghong yapinhibitionblocksuvealmelanogenesisdrivenbygnaqorgna11mutations
AT yufaxing yapinhibitionblocksuvealmelanogenesisdrivenbygnaqorgna11mutations
AT guankunliang yapinhibitionblocksuvealmelanogenesisdrivenbygnaqorgna11mutations
AT zhangkang yapinhibitionblocksuvealmelanogenesisdrivenbygnaqorgna11mutations

Ejemplares similares