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YAP inhibition blocks uveal melanogenesis driven by GNAQ or GNA11 mutations

Uveal melanoma (UM) is the most common adult intraocular tumor. UM often involves activating mutations in guanine nucleotide binding protein (G protein), q polypeptide (GQ), or G Protein, α 11 (G11). We show that the Yes-associated protein (Yap) inhibitor verteporfin blocks tumor growth of Gq/11-mut...

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Detalles Bibliográficos
Autores principales:	Lyubasyuk, Vera, Ouyang, Hong, Yu, Fa-Xing, Guan, Kun-Liang, Zhang, Kang
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Taylor & Francis 2014
Materias:	Author's View
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4905245/ https://www.ncbi.nlm.nih.gov/pubmed/27308390 http://dx.doi.org/10.4161/23723548.2014.970957

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