TRPV1: Turning up the heat on intestinal tumorigenesis

TRP channels are associated with the development and progression of cancer but their precise molecular roles in these processes are unclear. Recently, we showed that the transient receptor potential cation channel, subfamily V, member 1 (TRPV1) ion channel is part of a negative feedback loop downstr...

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Detalles Bibliográficos
Autores principales: de Jong, Petrus R, Bertin, Samuel, Raz, Eyal
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2014
Materias:
Author's View
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4905246/
https://www.ncbi.nlm.nih.gov/pubmed/27308393
http://dx.doi.org/10.4161/23723556.2014.975619
Descripción
Sumario:TRP channels are associated with the development and progression of cancer but their precise molecular roles in these processes are unclear. Recently, we showed that the transient receptor potential cation channel, subfamily V, member 1 (TRPV1) ion channel is part of a negative feedback loop downstream of epidermal growth factor receptor signaling that suppresses intestinal tumorigenesis.

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