Small molecule targeting miR-34a for cancer therapy

miR-34a functions as a tumor suppressor in many cancers. In a recent issue of Cancer Research, we describe a small molecule, Rubone, with strong anticancer activity. Rubone selectively restored miR-34a expression in hepatocellular carcinoma cells in which miR-34a was silenced. Restoration of miR-34a...

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Detalles Bibliográficos
Autores principales: Xiao, Zhangang, Chen, Yangchao
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2015
Materias:
Commentary
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4905251/
https://www.ncbi.nlm.nih.gov/pubmed/27308410
http://dx.doi.org/10.4161/23723556.2014.977160
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author Xiao, Zhangang
Chen, Yangchao
author_facet Xiao, Zhangang
Chen, Yangchao
author_sort Xiao, Zhangang
collection PubMed
description miR-34a functions as a tumor suppressor in many cancers. In a recent issue of Cancer Research, we describe a small molecule, Rubone, with strong anticancer activity. Rubone selectively restored miR-34a expression in hepatocellular carcinoma cells in which miR-34a was silenced. Restoration of miR-34a by Rubone represents a promising therapeutic approach against cancer.
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spelling pubmed-49052512016-06-15 Small molecule targeting miR-34a for cancer therapy Xiao, Zhangang Chen, Yangchao Mol Cell Oncol Commentary miR-34a functions as a tumor suppressor in many cancers. In a recent issue of Cancer Research, we describe a small molecule, Rubone, with strong anticancer activity. Rubone selectively restored miR-34a expression in hepatocellular carcinoma cells in which miR-34a was silenced. Restoration of miR-34a by Rubone represents a promising therapeutic approach against cancer. Taylor & Francis 2015-02-24 /pmc/articles/PMC4905251/ /pubmed/27308410 http://dx.doi.org/10.4161/23723556.2014.977160 Text en © 2015 The Author(s). Published with license by Taylor & Francis Group, LLC http://creativecommons.org/licenses/by-nc/3.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution-Non-Commercial License http://creativecommons.org/licenses/by-nc/3.0/, which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. The moral rights of the named author(s) have been asserted.
spellingShingle Commentary
Xiao, Zhangang
Chen, Yangchao
Small molecule targeting miR-34a for cancer therapy
title Small molecule targeting miR-34a for cancer therapy
title_full Small molecule targeting miR-34a for cancer therapy
title_fullStr Small molecule targeting miR-34a for cancer therapy
title_full_unstemmed Small molecule targeting miR-34a for cancer therapy
title_short Small molecule targeting miR-34a for cancer therapy
title_sort small molecule targeting mir-34a for cancer therapy
topic Commentary
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4905251/
https://www.ncbi.nlm.nih.gov/pubmed/27308410
http://dx.doi.org/10.4161/23723556.2014.977160
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