p62: a hub of multiple signaling pathways in HER2-induced mammary tumorigenesis

We recently reported that depletion of p62 in the background of human epidermal growth factor receptor 2 (HER2) overexpression sensitizes mammary tumor cells to amino acid deprivation, abolishes cellular transformation in vitro, and suppresses mammary tumorigenesis in vivo. Extensive investigation o...

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Detalles Bibliográficos
Autores principales: Cai-McRae, Xiaofeng, Karantza, Vassiliki
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2015
Materias:
Commentary
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4905285/
https://www.ncbi.nlm.nih.gov/pubmed/27308451
http://dx.doi.org/10.4161/23723556.2014.975035
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author Cai-McRae, Xiaofeng
Karantza, Vassiliki
author_facet Cai-McRae, Xiaofeng
Karantza, Vassiliki
author_sort Cai-McRae, Xiaofeng
collection PubMed
description We recently reported that depletion of p62 in the background of human epidermal growth factor receptor 2 (HER2) overexpression sensitizes mammary tumor cells to amino acid deprivation, abolishes cellular transformation in vitro, and suppresses mammary tumorigenesis in vivo. Extensive investigation on the underlying molecular mechanisms has revealed a multifaceted role for p62 in HER2-associated mammary tumorigenesis.
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spelling pubmed-49052852016-06-15 p62: a hub of multiple signaling pathways in HER2-induced mammary tumorigenesis Cai-McRae, Xiaofeng Karantza, Vassiliki Mol Cell Oncol Commentary We recently reported that depletion of p62 in the background of human epidermal growth factor receptor 2 (HER2) overexpression sensitizes mammary tumor cells to amino acid deprivation, abolishes cellular transformation in vitro, and suppresses mammary tumorigenesis in vivo. Extensive investigation on the underlying molecular mechanisms has revealed a multifaceted role for p62 in HER2-associated mammary tumorigenesis. Taylor & Francis 2015-03-17 /pmc/articles/PMC4905285/ /pubmed/27308451 http://dx.doi.org/10.4161/23723556.2014.975035 Text en © 2015 The Author(s). Published with license by Taylor & Francis Group, LLC http://creativecommons.org/licenses/by-nc/3.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution-Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/), which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. The moral rights of the named author(s) have been asserted.
spellingShingle Commentary
Cai-McRae, Xiaofeng
Karantza, Vassiliki
p62: a hub of multiple signaling pathways in HER2-induced mammary tumorigenesis
title p62: a hub of multiple signaling pathways in HER2-induced mammary tumorigenesis
title_full p62: a hub of multiple signaling pathways in HER2-induced mammary tumorigenesis
title_fullStr p62: a hub of multiple signaling pathways in HER2-induced mammary tumorigenesis
title_full_unstemmed p62: a hub of multiple signaling pathways in HER2-induced mammary tumorigenesis
title_short p62: a hub of multiple signaling pathways in HER2-induced mammary tumorigenesis
title_sort p62: a hub of multiple signaling pathways in her2-induced mammary tumorigenesis
topic Commentary
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4905285/
https://www.ncbi.nlm.nih.gov/pubmed/27308451
http://dx.doi.org/10.4161/23723556.2014.975035
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