Cargando…
TRIB3 suppresses tumorigenesis by controlling mTORC2/AKT/FOXO signaling
In a recent article, we found that Tribbles pseudokinase 3 (TRIB3) plays a tumor suppressor role and that this effect relies on the dysregulation of the phosphorylation of v-akt murine thymoma viral oncogene homolog (AKT) by the mammalian target of rapamycin complex 2 (mTORC2 complex), and the subse...
| Autores principales: | , , , , , , , , , , , , , , , , , , , , , |
|---|---|
| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Taylor & Francis
2015
|
| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4905291/ https://www.ncbi.nlm.nih.gov/pubmed/27308456 http://dx.doi.org/10.4161/23723556.2014.980134 |
| _version_ | 1782437241422872576 |
|---|---|
| author | Salazar, María Lorente, Mar García-Taboada, Elena Gómez, Eduardo Pérez Dávila, David Zúñiga-García, Patricia Flores, Juana M Rodríguez, Antonio Hegedus, Zoltan Mosén-Ansorena, David Aransay, Ana M Hernández-Tiedra, Sonia López-Valero, Israel Quintanilla, Miguel Sánchez, Cristina Iovanna, Juan L Dusetti, Nelson Guzmán, Manuel Francis, Sheila E Carracedo, Arkaitz Kiss-Toth, Endre Velasco, Guillermo |
| author_facet | Salazar, María Lorente, Mar García-Taboada, Elena Gómez, Eduardo Pérez Dávila, David Zúñiga-García, Patricia Flores, Juana M Rodríguez, Antonio Hegedus, Zoltan Mosén-Ansorena, David Aransay, Ana M Hernández-Tiedra, Sonia López-Valero, Israel Quintanilla, Miguel Sánchez, Cristina Iovanna, Juan L Dusetti, Nelson Guzmán, Manuel Francis, Sheila E Carracedo, Arkaitz Kiss-Toth, Endre Velasco, Guillermo |
| author_sort | Salazar, María |
| collection | PubMed |
| description | In a recent article, we found that Tribbles pseudokinase 3 (TRIB3) plays a tumor suppressor role and that this effect relies on the dysregulation of the phosphorylation of v-akt murine thymoma viral oncogene homolog (AKT) by the mammalian target of rapamycin complex 2 (mTORC2 complex), and the subsequent hyperphosphorylation and inactivation of the transcription factor Forkhead box O3 (FOXO3). |
| format | Online Article Text |
| id | pubmed-4905291 |
| institution | National Center for Biotechnology Information |
| language | English |
| publishDate | 2015 |
| publisher | Taylor & Francis |
| record_format | MEDLINE/PubMed |
| spelling | pubmed-49052912016-06-15 TRIB3 suppresses tumorigenesis by controlling mTORC2/AKT/FOXO signaling Salazar, María Lorente, Mar García-Taboada, Elena Gómez, Eduardo Pérez Dávila, David Zúñiga-García, Patricia Flores, Juana M Rodríguez, Antonio Hegedus, Zoltan Mosén-Ansorena, David Aransay, Ana M Hernández-Tiedra, Sonia López-Valero, Israel Quintanilla, Miguel Sánchez, Cristina Iovanna, Juan L Dusetti, Nelson Guzmán, Manuel Francis, Sheila E Carracedo, Arkaitz Kiss-Toth, Endre Velasco, Guillermo Mol Cell Oncol Author's Views In a recent article, we found that Tribbles pseudokinase 3 (TRIB3) plays a tumor suppressor role and that this effect relies on the dysregulation of the phosphorylation of v-akt murine thymoma viral oncogene homolog (AKT) by the mammalian target of rapamycin complex 2 (mTORC2 complex), and the subsequent hyperphosphorylation and inactivation of the transcription factor Forkhead box O3 (FOXO3). Taylor & Francis 2015-04-18 /pmc/articles/PMC4905291/ /pubmed/27308456 http://dx.doi.org/10.4161/23723556.2014.980134 Text en © 2015 The Author(s). Published with license by Taylor & Francis Group, LLC http://creativecommons.org/licenses/by-nc/3.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution-Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/), which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. The moral rights of the named author(s) have been asserted. |
| spellingShingle | Author's Views Salazar, María Lorente, Mar García-Taboada, Elena Gómez, Eduardo Pérez Dávila, David Zúñiga-García, Patricia Flores, Juana M Rodríguez, Antonio Hegedus, Zoltan Mosén-Ansorena, David Aransay, Ana M Hernández-Tiedra, Sonia López-Valero, Israel Quintanilla, Miguel Sánchez, Cristina Iovanna, Juan L Dusetti, Nelson Guzmán, Manuel Francis, Sheila E Carracedo, Arkaitz Kiss-Toth, Endre Velasco, Guillermo TRIB3 suppresses tumorigenesis by controlling mTORC2/AKT/FOXO signaling |
| title | TRIB3 suppresses tumorigenesis by controlling mTORC2/AKT/FOXO signaling |
| title_full | TRIB3 suppresses tumorigenesis by controlling mTORC2/AKT/FOXO signaling |
| title_fullStr | TRIB3 suppresses tumorigenesis by controlling mTORC2/AKT/FOXO signaling |
| title_full_unstemmed | TRIB3 suppresses tumorigenesis by controlling mTORC2/AKT/FOXO signaling |
| title_short | TRIB3 suppresses tumorigenesis by controlling mTORC2/AKT/FOXO signaling |
| title_sort | trib3 suppresses tumorigenesis by controlling mtorc2/akt/foxo signaling |
| topic | Author's Views |
| url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4905291/ https://www.ncbi.nlm.nih.gov/pubmed/27308456 http://dx.doi.org/10.4161/23723556.2014.980134 |
| work_keys_str_mv | AT salazarmaria trib3suppressestumorigenesisbycontrollingmtorc2aktfoxosignaling AT lorentemar trib3suppressestumorigenesisbycontrollingmtorc2aktfoxosignaling AT garciataboadaelena trib3suppressestumorigenesisbycontrollingmtorc2aktfoxosignaling AT gomezeduardoperez trib3suppressestumorigenesisbycontrollingmtorc2aktfoxosignaling AT daviladavid trib3suppressestumorigenesisbycontrollingmtorc2aktfoxosignaling AT zunigagarciapatricia trib3suppressestumorigenesisbycontrollingmtorc2aktfoxosignaling AT floresjuanam trib3suppressestumorigenesisbycontrollingmtorc2aktfoxosignaling AT rodriguezantonio trib3suppressestumorigenesisbycontrollingmtorc2aktfoxosignaling AT hegeduszoltan trib3suppressestumorigenesisbycontrollingmtorc2aktfoxosignaling AT mosenansorenadavid trib3suppressestumorigenesisbycontrollingmtorc2aktfoxosignaling AT aransayanam trib3suppressestumorigenesisbycontrollingmtorc2aktfoxosignaling AT hernandeztiedrasonia trib3suppressestumorigenesisbycontrollingmtorc2aktfoxosignaling AT lopezvaleroisrael trib3suppressestumorigenesisbycontrollingmtorc2aktfoxosignaling AT quintanillamiguel trib3suppressestumorigenesisbycontrollingmtorc2aktfoxosignaling AT sanchezcristina trib3suppressestumorigenesisbycontrollingmtorc2aktfoxosignaling AT iovannajuanl trib3suppressestumorigenesisbycontrollingmtorc2aktfoxosignaling AT dusettinelson trib3suppressestumorigenesisbycontrollingmtorc2aktfoxosignaling AT guzmanmanuel trib3suppressestumorigenesisbycontrollingmtorc2aktfoxosignaling AT francissheilae trib3suppressestumorigenesisbycontrollingmtorc2aktfoxosignaling AT carracedoarkaitz trib3suppressestumorigenesisbycontrollingmtorc2aktfoxosignaling AT kisstothendre trib3suppressestumorigenesisbycontrollingmtorc2aktfoxosignaling AT velascoguillermo trib3suppressestumorigenesisbycontrollingmtorc2aktfoxosignaling |