The PHD motif of Map3k1 activates cytokine-dependent MAPK signaling

We generated a mutation in the gene encoding mitogen-activated protein kinase kinase kinase 1 (Map3k1) that results in a protein with an inactive plant homeodomain (PHD). Map3k1(mPHD) cells are defective in cytokine-mediated MAPK signaling. Protein array identified transforming growth factor (TGF-β)...

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Autores principales: Gallagher, Ewen, Suddason, Tesha
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2015
Materias:
Author's Views
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4905292/
https://www.ncbi.nlm.nih.gov/pubmed/27308457
http://dx.doi.org/10.4161/23723556.2014.980659
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author Gallagher, Ewen
Suddason, Tesha
author_facet Gallagher, Ewen
Suddason, Tesha
author_sort Gallagher, Ewen
collection PubMed
description We generated a mutation in the gene encoding mitogen-activated protein kinase kinase kinase 1 (Map3k1) that results in a protein with an inactive plant homeodomain (PHD). Map3k1(mPHD) cells are defective in cytokine-mediated MAPK signaling. Protein array identified transforming growth factor (TGF-β)-activated kinase 1 binding protein 1 (Tab1) as a PHD substrate. The Map3k1 PHD transfers Lys63-linked poly-ubiquitin onto Tab1 to activate MAPKs.
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spelling pubmed-49052922016-06-15 The PHD motif of Map3k1 activates cytokine-dependent MAPK signaling Gallagher, Ewen Suddason, Tesha Mol Cell Oncol Author's Views We generated a mutation in the gene encoding mitogen-activated protein kinase kinase kinase 1 (Map3k1) that results in a protein with an inactive plant homeodomain (PHD). Map3k1(mPHD) cells are defective in cytokine-mediated MAPK signaling. Protein array identified transforming growth factor (TGF-β)-activated kinase 1 binding protein 1 (Tab1) as a PHD substrate. The Map3k1 PHD transfers Lys63-linked poly-ubiquitin onto Tab1 to activate MAPKs. Taylor & Francis 2015-05-06 /pmc/articles/PMC4905292/ /pubmed/27308457 http://dx.doi.org/10.4161/23723556.2014.980659 Text en © 2015 The Author(s). Published with license by Taylor & Francis Group, LLC http://creativecommons.org/licenses/by-nc/3.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution-Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/), which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. The moral rights of the named author(s) have been asserted.
spellingShingle Author's Views
Gallagher, Ewen
Suddason, Tesha
The PHD motif of Map3k1 activates cytokine-dependent MAPK signaling
title The PHD motif of Map3k1 activates cytokine-dependent MAPK signaling
title_full The PHD motif of Map3k1 activates cytokine-dependent MAPK signaling
title_fullStr The PHD motif of Map3k1 activates cytokine-dependent MAPK signaling
title_full_unstemmed The PHD motif of Map3k1 activates cytokine-dependent MAPK signaling
title_short The PHD motif of Map3k1 activates cytokine-dependent MAPK signaling
title_sort phd motif of map3k1 activates cytokine-dependent mapk signaling
topic Author's Views
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4905292/
https://www.ncbi.nlm.nih.gov/pubmed/27308457
http://dx.doi.org/10.4161/23723556.2014.980659
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