The cancer cell ‘energy grid’: TGF-β1 signaling coordinates metabolism for migration

Cancer cells have an increased reliance on lipogenesis, which is required for uncontrolled cell division. We recently reported transcriptional and functional ‘reprogramming’ of the cellular energy grid, allowing cancer cells to divert metabolism from biosynthesis to bioenergetic pathways and thus su...

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Detalles Bibliográficos
Autores principales: Jiang, Lei, Deberardinis, Ralph, Boothman, David A
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2015
Materias:
Commentary
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4905294/
https://www.ncbi.nlm.nih.gov/pubmed/27308459
http://dx.doi.org/10.4161/23723556.2014.981994
Descripción
Sumario:Cancer cells have an increased reliance on lipogenesis, which is required for uncontrolled cell division. We recently reported transcriptional and functional ‘reprogramming’ of the cellular energy grid, allowing cancer cells to divert metabolism from biosynthesis to bioenergetic pathways and thus supplying enhanced mobility during epithelial–mesenchymal transition (EMT) induced by transforming growth factor β (TGF-β1) (Fig. 1).

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