The cancer cell ‘energy grid’: TGF-β1 signaling coordinates metabolism for migration

Cancer cells have an increased reliance on lipogenesis, which is required for uncontrolled cell division. We recently reported transcriptional and functional ‘reprogramming’ of the cellular energy grid, allowing cancer cells to divert metabolism from biosynthesis to bioenergetic pathways and thus su...

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Detalles Bibliográficos
Autores principales: Jiang, Lei, Deberardinis, Ralph, Boothman, David A
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2015
Materias:
Commentary
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4905294/
https://www.ncbi.nlm.nih.gov/pubmed/27308459
http://dx.doi.org/10.4161/23723556.2014.981994
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author Jiang, Lei
Deberardinis, Ralph
Boothman, David A
author_facet Jiang, Lei
Deberardinis, Ralph
Boothman, David A
author_sort Jiang, Lei
collection PubMed
description Cancer cells have an increased reliance on lipogenesis, which is required for uncontrolled cell division. We recently reported transcriptional and functional ‘reprogramming’ of the cellular energy grid, allowing cancer cells to divert metabolism from biosynthesis to bioenergetic pathways and thus supplying enhanced mobility during epithelial–mesenchymal transition (EMT) induced by transforming growth factor β (TGF-β1) (Fig. 1).
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spelling pubmed-49052942016-06-15 The cancer cell ‘energy grid’: TGF-β1 signaling coordinates metabolism for migration Jiang, Lei Deberardinis, Ralph Boothman, David A Mol Cell Oncol Commentary Cancer cells have an increased reliance on lipogenesis, which is required for uncontrolled cell division. We recently reported transcriptional and functional ‘reprogramming’ of the cellular energy grid, allowing cancer cells to divert metabolism from biosynthesis to bioenergetic pathways and thus supplying enhanced mobility during epithelial–mesenchymal transition (EMT) induced by transforming growth factor β (TGF-β1) (Fig. 1). Taylor & Francis 2015-01-07 /pmc/articles/PMC4905294/ /pubmed/27308459 http://dx.doi.org/10.4161/23723556.2014.981994 Text en © 2015 The Author(s). Published with license by Taylor & Francis Group, LLC http://creativecommons.org/licenses/by-nc/3.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution-Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/), which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. The moral rights of the named author(s) have been asserted.
spellingShingle Commentary
Jiang, Lei
Deberardinis, Ralph
Boothman, David A
The cancer cell ‘energy grid’: TGF-β1 signaling coordinates metabolism for migration
title The cancer cell ‘energy grid’: TGF-β1 signaling coordinates metabolism for migration
title_full The cancer cell ‘energy grid’: TGF-β1 signaling coordinates metabolism for migration
title_fullStr The cancer cell ‘energy grid’: TGF-β1 signaling coordinates metabolism for migration
title_full_unstemmed The cancer cell ‘energy grid’: TGF-β1 signaling coordinates metabolism for migration
title_short The cancer cell ‘energy grid’: TGF-β1 signaling coordinates metabolism for migration
title_sort cancer cell ‘energy grid’: tgf-β1 signaling coordinates metabolism for migration
topic Commentary
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4905294/
https://www.ncbi.nlm.nih.gov/pubmed/27308459
http://dx.doi.org/10.4161/23723556.2014.981994
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