Ribosome heterogeneity in tumorigenesis: the rRNA point of view

The "specialized ribosome" concept proposes that ribosome variants are produced and differentially regulate translation. Examples supporting this notion demonstrated heterogeneity of ribosomal protein composition. However, ribosome translational activity is carried out by rRNA. We, and oth...

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Detalles Bibliográficos
Autores principales: Marcel, Virginie, Catez, Frédéric, Diaz, Jean-Jacques
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2015
Materias:
Commentary
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4905297/
https://www.ncbi.nlm.nih.gov/pubmed/27305893
http://dx.doi.org/10.4161/23723556.2014.983755
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author Marcel, Virginie
Catez, Frédéric
Diaz, Jean-Jacques
author_facet Marcel, Virginie
Catez, Frédéric
Diaz, Jean-Jacques
author_sort Marcel, Virginie
collection PubMed
description The "specialized ribosome" concept proposes that ribosome variants are produced and differentially regulate translation. Examples supporting this notion demonstrated heterogeneity of ribosomal protein composition. However, ribosome translational activity is carried out by rRNA. We, and others, recently showed that rRNA heterogeneity regulates translation to generate distinct translatomes promoting tumorigenesis.
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spelling pubmed-49052972016-06-15 Ribosome heterogeneity in tumorigenesis: the rRNA point of view Marcel, Virginie Catez, Frédéric Diaz, Jean-Jacques Mol Cell Oncol Commentary The "specialized ribosome" concept proposes that ribosome variants are produced and differentially regulate translation. Examples supporting this notion demonstrated heterogeneity of ribosomal protein composition. However, ribosome translational activity is carried out by rRNA. We, and others, recently showed that rRNA heterogeneity regulates translation to generate distinct translatomes promoting tumorigenesis. Taylor & Francis 2015-03-24 /pmc/articles/PMC4905297/ /pubmed/27305893 http://dx.doi.org/10.4161/23723556.2014.983755 Text en © 2015 The Author(s). Published with license by Taylor & Francis Group, LLC http://creativecommons.org/licenses/by-nc/3.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution-Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/), which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. The moral rights of the named author(s) have been asserted.
spellingShingle Commentary
Marcel, Virginie
Catez, Frédéric
Diaz, Jean-Jacques
Ribosome heterogeneity in tumorigenesis: the rRNA point of view
title Ribosome heterogeneity in tumorigenesis: the rRNA point of view
title_full Ribosome heterogeneity in tumorigenesis: the rRNA point of view
title_fullStr Ribosome heterogeneity in tumorigenesis: the rRNA point of view
title_full_unstemmed Ribosome heterogeneity in tumorigenesis: the rRNA point of view
title_short Ribosome heterogeneity in tumorigenesis: the rRNA point of view
title_sort ribosome heterogeneity in tumorigenesis: the rrna point of view
topic Commentary
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4905297/
https://www.ncbi.nlm.nih.gov/pubmed/27305893
http://dx.doi.org/10.4161/23723556.2014.983755
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