Flicking the molecular switch underlying MLKL-mediated necroptosis

The pseudokinase domain of the necroptosis effector mixed lineage kinase domain-like (MLKL) functions as a latch to restrain the unleashing of its N-terminal 4-helix bundle (4HB) domain. Cell death mediated by the 4HB domain relies on membrane association and oligomerization, which can be inhibited...

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Detalles Bibliográficos
Autores principales: Hildebrand, Joanne M, Lucet, Isabelle S, Murphy, James M
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2015
Materias:
Author's Views
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4905300/
https://www.ncbi.nlm.nih.gov/pubmed/27308464
http://dx.doi.org/10.4161/23723556.2014.985550
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author Hildebrand, Joanne M
Lucet, Isabelle S
Murphy, James M
author_facet Hildebrand, Joanne M
Lucet, Isabelle S
Murphy, James M
author_sort Hildebrand, Joanne M
collection PubMed
description The pseudokinase domain of the necroptosis effector mixed lineage kinase domain-like (MLKL) functions as a latch to restrain the unleashing of its N-terminal 4-helix bundle (4HB) domain. Cell death mediated by the 4HB domain relies on membrane association and oligomerization, which can be inhibited by an ATP-mimetic small molecule that binds the pseudokinase domain of MLKL.
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spelling pubmed-49053002016-06-15 Flicking the molecular switch underlying MLKL-mediated necroptosis Hildebrand, Joanne M Lucet, Isabelle S Murphy, James M Mol Cell Oncol Author's Views The pseudokinase domain of the necroptosis effector mixed lineage kinase domain-like (MLKL) functions as a latch to restrain the unleashing of its N-terminal 4-helix bundle (4HB) domain. Cell death mediated by the 4HB domain relies on membrane association and oligomerization, which can be inhibited by an ATP-mimetic small molecule that binds the pseudokinase domain of MLKL. Taylor & Francis 2015-01-23 /pmc/articles/PMC4905300/ /pubmed/27308464 http://dx.doi.org/10.4161/23723556.2014.985550 Text en © 2015 The Author(s). Published with license by Taylor & Francis Group, LLC http://creativecommons.org/licenses/by-nc/3.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution-Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/), which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. The moral rights of the named author(s) have been asserted.
spellingShingle Author's Views
Hildebrand, Joanne M
Lucet, Isabelle S
Murphy, James M
Flicking the molecular switch underlying MLKL-mediated necroptosis
title Flicking the molecular switch underlying MLKL-mediated necroptosis
title_full Flicking the molecular switch underlying MLKL-mediated necroptosis
title_fullStr Flicking the molecular switch underlying MLKL-mediated necroptosis
title_full_unstemmed Flicking the molecular switch underlying MLKL-mediated necroptosis
title_short Flicking the molecular switch underlying MLKL-mediated necroptosis
title_sort flicking the molecular switch underlying mlkl-mediated necroptosis
topic Author's Views
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4905300/
https://www.ncbi.nlm.nih.gov/pubmed/27308464
http://dx.doi.org/10.4161/23723556.2014.985550
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