Playing musical chairs with bone marrow transplantation to eliminate leukemia stem cells

Increasing attention has been focused on the interactions between leukemia cells and their bone marrow (BM) microenvironment. We have recently shown that leukemic stem cells (LSCs) share common BM “niches” with their healthy counterparts. As a result of these shared niche requirements, human LSCs ca...

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Detalles Bibliográficos
Autores principales: Boyd, Allison L, Bhatia, Mickie
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2015
Materias:
Commentary
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4905304/
https://www.ncbi.nlm.nih.gov/pubmed/27308468
http://dx.doi.org/10.4161/23723556.2014.988480
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author Boyd, Allison L
Bhatia, Mickie
author_facet Boyd, Allison L
Bhatia, Mickie
author_sort Boyd, Allison L
collection PubMed
description Increasing attention has been focused on the interactions between leukemia cells and their bone marrow (BM) microenvironment. We have recently shown that leukemic stem cells (LSCs) share common BM “niches” with their healthy counterparts. As a result of these shared niche requirements, human LSCs can be mobilized using existing pharmacological agents that facilitate competitive healthy reconstitution, leading to eradication of leukemia during BM transplantation.
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spelling pubmed-49053042016-06-15 Playing musical chairs with bone marrow transplantation to eliminate leukemia stem cells Boyd, Allison L Bhatia, Mickie Mol Cell Oncol Commentary Increasing attention has been focused on the interactions between leukemia cells and their bone marrow (BM) microenvironment. We have recently shown that leukemic stem cells (LSCs) share common BM “niches” with their healthy counterparts. As a result of these shared niche requirements, human LSCs can be mobilized using existing pharmacological agents that facilitate competitive healthy reconstitution, leading to eradication of leukemia during BM transplantation. Taylor & Francis 2015-03-19 /pmc/articles/PMC4905304/ /pubmed/27308468 http://dx.doi.org/10.4161/23723556.2014.988480 Text en © 2015 The Author(s). Published with license by Taylor & Francis Group, LLC http://creativecommons.org/licenses/by-nc/3.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution-Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/), which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. The moral rights of the named author(s) have been asserted.
spellingShingle Commentary
Boyd, Allison L
Bhatia, Mickie
Playing musical chairs with bone marrow transplantation to eliminate leukemia stem cells
title Playing musical chairs with bone marrow transplantation to eliminate leukemia stem cells
title_full Playing musical chairs with bone marrow transplantation to eliminate leukemia stem cells
title_fullStr Playing musical chairs with bone marrow transplantation to eliminate leukemia stem cells
title_full_unstemmed Playing musical chairs with bone marrow transplantation to eliminate leukemia stem cells
title_short Playing musical chairs with bone marrow transplantation to eliminate leukemia stem cells
title_sort playing musical chairs with bone marrow transplantation to eliminate leukemia stem cells
topic Commentary
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4905304/
https://www.ncbi.nlm.nih.gov/pubmed/27308468
http://dx.doi.org/10.4161/23723556.2014.988480
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