TRF2 acts as a transcriptional regulator in tumor angiogenesis

We recently showed that telomeric repeat-binding factor 2 (TRF2) regulates gene expression to promote angiogenesis. We found that TRF2 is highly expressed in tumor vessels and transcriptionally activates platelet-derived growth factor receptor β to promote endothelial cell angiogenic properties inde...

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Detalles Bibliográficos
Autores principales: Maï, Mounir El, Wagner, Kay-Dietrich, Michiels, Jean-François, Gilson, Eric, Wagner, Nicole
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2015
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4905305/
https://www.ncbi.nlm.nih.gov/pubmed/27308469
http://dx.doi.org/10.4161/23723556.2014.988508
Descripción
Sumario:We recently showed that telomeric repeat-binding factor 2 (TRF2) regulates gene expression to promote angiogenesis. We found that TRF2 is highly expressed in tumor vessels and transcriptionally activates platelet-derived growth factor receptor β to promote endothelial cell angiogenic properties independently of its function in telomere protection. This work identifies TRF2 as a promising dual target for cancer therapy.

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