TRF2 acts as a transcriptional regulator in tumor angiogenesis

We recently showed that telomeric repeat-binding factor 2 (TRF2) regulates gene expression to promote angiogenesis. We found that TRF2 is highly expressed in tumor vessels and transcriptionally activates platelet-derived growth factor receptor β to promote endothelial cell angiogenic properties inde...

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Detalles Bibliográficos
Autores principales: Maï, Mounir El, Wagner, Kay-Dietrich, Michiels, Jean-François, Gilson, Eric, Wagner, Nicole
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2015
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4905305/
https://www.ncbi.nlm.nih.gov/pubmed/27308469
http://dx.doi.org/10.4161/23723556.2014.988508
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author Maï, Mounir El
Wagner, Kay-Dietrich
Michiels, Jean-François
Gilson, Eric
Wagner, Nicole
author_facet Maï, Mounir El
Wagner, Kay-Dietrich
Michiels, Jean-François
Gilson, Eric
Wagner, Nicole
author_sort Maï, Mounir El
collection PubMed
description We recently showed that telomeric repeat-binding factor 2 (TRF2) regulates gene expression to promote angiogenesis. We found that TRF2 is highly expressed in tumor vessels and transcriptionally activates platelet-derived growth factor receptor β to promote endothelial cell angiogenic properties independently of its function in telomere protection. This work identifies TRF2 as a promising dual target for cancer therapy.
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spelling pubmed-49053052016-06-15 TRF2 acts as a transcriptional regulator in tumor angiogenesis Maï, Mounir El Wagner, Kay-Dietrich Michiels, Jean-François Gilson, Eric Wagner, Nicole Mol Cell Oncol Research Paper We recently showed that telomeric repeat-binding factor 2 (TRF2) regulates gene expression to promote angiogenesis. We found that TRF2 is highly expressed in tumor vessels and transcriptionally activates platelet-derived growth factor receptor β to promote endothelial cell angiogenic properties independently of its function in telomere protection. This work identifies TRF2 as a promising dual target for cancer therapy. Taylor & Francis 2015-01-23 /pmc/articles/PMC4905305/ /pubmed/27308469 http://dx.doi.org/10.4161/23723556.2014.988508 Text en © 2015 The Author(s). Published with license by Taylor & Francis Group, LLC http://creativecommons.org/licenses/by-nc/3.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution-Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/), which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. The moral rights of the named author(s) have been asserted.
spellingShingle Research Paper
Maï, Mounir El
Wagner, Kay-Dietrich
Michiels, Jean-François
Gilson, Eric
Wagner, Nicole
TRF2 acts as a transcriptional regulator in tumor angiogenesis
title TRF2 acts as a transcriptional regulator in tumor angiogenesis
title_full TRF2 acts as a transcriptional regulator in tumor angiogenesis
title_fullStr TRF2 acts as a transcriptional regulator in tumor angiogenesis
title_full_unstemmed TRF2 acts as a transcriptional regulator in tumor angiogenesis
title_short TRF2 acts as a transcriptional regulator in tumor angiogenesis
title_sort trf2 acts as a transcriptional regulator in tumor angiogenesis
topic Research Paper
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4905305/
https://www.ncbi.nlm.nih.gov/pubmed/27308469
http://dx.doi.org/10.4161/23723556.2014.988508
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AT gilsoneric trf2actsasatranscriptionalregulatorintumorangiogenesis
AT wagnernicole trf2actsasatranscriptionalregulatorintumorangiogenesis

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