The cancer stem cell phenotype: You can't win until you learn how to lose it

Cancer stem cells and their relatively differentiated progenitors coexist in dynamic equilibrium and are subject to bidirectional conversion. We recently showed that reprogramming transcription factors induce glioblastoma cells to become stem-like and tumor propagating via a mechanism involving chan...

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Detalles Bibliográficos
Autores principales: Lopez-Bertoni, Hernando, Laterra, John
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2015
Materias:
Author's View
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4905306/
https://www.ncbi.nlm.nih.gov/pubmed/27308470
http://dx.doi.org/10.4161/23723556.2014.989760
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author Lopez-Bertoni, Hernando
Laterra, John
author_facet Lopez-Bertoni, Hernando
Laterra, John
author_sort Lopez-Bertoni, Hernando
collection PubMed
description Cancer stem cells and their relatively differentiated progenitors coexist in dynamic equilibrium and are subject to bidirectional conversion. We recently showed that reprogramming transcription factors induce glioblastoma cells to become stem-like and tumor propagating via a mechanism involving changes in global DNA methylation and downregulation of miRNAs.
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spelling pubmed-49053062016-06-15 The cancer stem cell phenotype: You can't win until you learn how to lose it Lopez-Bertoni, Hernando Laterra, John Mol Cell Oncol Author's View Cancer stem cells and their relatively differentiated progenitors coexist in dynamic equilibrium and are subject to bidirectional conversion. We recently showed that reprogramming transcription factors induce glioblastoma cells to become stem-like and tumor propagating via a mechanism involving changes in global DNA methylation and downregulation of miRNAs. Taylor & Francis 2015-01-23 /pmc/articles/PMC4905306/ /pubmed/27308470 http://dx.doi.org/10.4161/23723556.2014.989760 Text en © 2015 The Author(s). Published with license by Taylor & Francis Group, LLC http://creativecommons.org/licenses/by-nc/3.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution-Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/), which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. The moral rights of the named author(s) have been asserted.
spellingShingle Author's View
Lopez-Bertoni, Hernando
Laterra, John
The cancer stem cell phenotype: You can't win until you learn how to lose it
title The cancer stem cell phenotype: You can't win until you learn how to lose it
title_full The cancer stem cell phenotype: You can't win until you learn how to lose it
title_fullStr The cancer stem cell phenotype: You can't win until you learn how to lose it
title_full_unstemmed The cancer stem cell phenotype: You can't win until you learn how to lose it
title_short The cancer stem cell phenotype: You can't win until you learn how to lose it
title_sort cancer stem cell phenotype: you can't win until you learn how to lose it
topic Author's View
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4905306/
https://www.ncbi.nlm.nih.gov/pubmed/27308470
http://dx.doi.org/10.4161/23723556.2014.989760
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