Restoration of tumor suppressor functions by small-molecule inhibitors

Over the last decades, accumulating data have advanced our understanding of the mechanism of action of tumor suppressor proteins and therapeutic strategies to restore tumor suppressor pathways have emerged as a promising approach for cancer therapy. Based on our recent findings on bridging integrato...

Descripción completa

Detalles Bibliográficos
Autores principales: Pyndiah, Slovénie, Sakamuro, Daitoku
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2015
Materias:
Author's Views
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4905308/
https://www.ncbi.nlm.nih.gov/pubmed/27308472
http://dx.doi.org/10.4161/23723556.2014.991225
_version_ 1782437244846473216
author Pyndiah, Slovénie
Sakamuro, Daitoku
author_facet Pyndiah, Slovénie
Sakamuro, Daitoku
author_sort Pyndiah, Slovénie
collection PubMed
description Over the last decades, accumulating data have advanced our understanding of the mechanism of action of tumor suppressor proteins and therapeutic strategies to restore tumor suppressor pathways have emerged as a promising approach for cancer therapy. Based on our recent findings on bridging integrator-1 (BIN1), we outline potential advantages and disadvantages of chemical activation of tumor suppressors.
format Online
Article
Text
id pubmed-4905308
institution National Center for Biotechnology Information
language English
publishDate 2015
publisher Taylor & Francis
record_format MEDLINE/PubMed
spelling pubmed-49053082016-06-15 Restoration of tumor suppressor functions by small-molecule inhibitors Pyndiah, Slovénie Sakamuro, Daitoku Mol Cell Oncol Author's Views Over the last decades, accumulating data have advanced our understanding of the mechanism of action of tumor suppressor proteins and therapeutic strategies to restore tumor suppressor pathways have emerged as a promising approach for cancer therapy. Based on our recent findings on bridging integrator-1 (BIN1), we outline potential advantages and disadvantages of chemical activation of tumor suppressors. Taylor & Francis 2015-01-23 /pmc/articles/PMC4905308/ /pubmed/27308472 http://dx.doi.org/10.4161/23723556.2014.991225 Text en © 2015 The Author(s). Published with license by Taylor & Francis Group, LLC http://creativecommons.org/licenses/by-nc/3.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution-Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/), which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. The moral rights of the named author(s) have been asserted.
spellingShingle Author's Views
Pyndiah, Slovénie
Sakamuro, Daitoku
Restoration of tumor suppressor functions by small-molecule inhibitors
title Restoration of tumor suppressor functions by small-molecule inhibitors
title_full Restoration of tumor suppressor functions by small-molecule inhibitors
title_fullStr Restoration of tumor suppressor functions by small-molecule inhibitors
title_full_unstemmed Restoration of tumor suppressor functions by small-molecule inhibitors
title_short Restoration of tumor suppressor functions by small-molecule inhibitors
title_sort restoration of tumor suppressor functions by small-molecule inhibitors
topic Author's Views
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4905308/
https://www.ncbi.nlm.nih.gov/pubmed/27308472
http://dx.doi.org/10.4161/23723556.2014.991225
work_keys_str_mv AT pyndiahslovenie restorationoftumorsuppressorfunctionsbysmallmoleculeinhibitors
AT sakamurodaitoku restorationoftumorsuppressorfunctionsbysmallmoleculeinhibitors

Ejemplares similares