ROS signaling during granzyme B-mediated apoptosis

Reactive oxygen species (ROS) are involved in cell signaling, aging, and death and play a role in carcinogenesis. However, whether ROS are bystanders or active effectors of apoptosis was unclear until recently. New evidence shows that the killer lymphocyte protease granzyme B activates a conserved b...

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Detalles Bibliográficos
Autor principal: Martinvalet, Denis
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2015
Materias:
Author's Views
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4905311/
https://www.ncbi.nlm.nih.gov/pubmed/27308474
http://dx.doi.org/10.4161/23723556.2014.992639
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author Martinvalet, Denis
author_facet Martinvalet, Denis
author_sort Martinvalet, Denis
collection PubMed
description Reactive oxygen species (ROS) are involved in cell signaling, aging, and death and play a role in carcinogenesis. However, whether ROS are bystanders or active effectors of apoptosis was unclear until recently. New evidence shows that the killer lymphocyte protease granzyme B activates a conserved biochemical pathway centered on respiratory chain disruption to trigger mitocentric ROS-dependent apoptosis.
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spelling pubmed-49053112016-06-15 ROS signaling during granzyme B-mediated apoptosis Martinvalet, Denis Mol Cell Oncol Author's Views Reactive oxygen species (ROS) are involved in cell signaling, aging, and death and play a role in carcinogenesis. However, whether ROS are bystanders or active effectors of apoptosis was unclear until recently. New evidence shows that the killer lymphocyte protease granzyme B activates a conserved biochemical pathway centered on respiratory chain disruption to trigger mitocentric ROS-dependent apoptosis. Taylor & Francis 2015-01-26 /pmc/articles/PMC4905311/ /pubmed/27308474 http://dx.doi.org/10.4161/23723556.2014.992639 Text en © 2015 The Author(s). Published with license by Taylor & Francis Group, LLC http://creativecommons.org/licenses/by-nc/3.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution-Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/), which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. The moral rights of the named author(s) have been asserted.
spellingShingle Author's Views
Martinvalet, Denis
ROS signaling during granzyme B-mediated apoptosis
title ROS signaling during granzyme B-mediated apoptosis
title_full ROS signaling during granzyme B-mediated apoptosis
title_fullStr ROS signaling during granzyme B-mediated apoptosis
title_full_unstemmed ROS signaling during granzyme B-mediated apoptosis
title_short ROS signaling during granzyme B-mediated apoptosis
title_sort ros signaling during granzyme b-mediated apoptosis
topic Author's Views
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4905311/
https://www.ncbi.nlm.nih.gov/pubmed/27308474
http://dx.doi.org/10.4161/23723556.2014.992639
work_keys_str_mv AT martinvaletdenis rossignalingduringgranzymebmediatedapoptosis

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