Fateful music from a talented orchestra with a wicked conductor: Connection between oncogenic BRAF, ER stress, and autophagy in human melanoma

Autophagy and endoplasmic reticulum (ER) stress are involved in the development, progression, and chemoresistance of melanoma. We recently reported that oncogenic serine/threonine-protein kinase BRAF induces chronic ER stress, hence increasing baseline autophagy and promoting chemoresistance. The at...

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Autores principales: Giglio, Paola, Fimia, Gian Maria, Lovat, Penny E, Piacentini, Mauro, Corazzari, Marco
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2015
Materias:
Author's Views
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4905314/
https://www.ncbi.nlm.nih.gov/pubmed/27308477
http://dx.doi.org/10.4161/23723556.2014.995016
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author Giglio, Paola
Fimia, Gian Maria
Lovat, Penny E
Piacentini, Mauro
Corazzari, Marco
author_facet Giglio, Paola
Fimia, Gian Maria
Lovat, Penny E
Piacentini, Mauro
Corazzari, Marco
author_sort Giglio, Paola
collection PubMed
description Autophagy and endoplasmic reticulum (ER) stress are involved in the development, progression, and chemoresistance of melanoma. We recently reported that oncogenic serine/threonine-protein kinase BRAF induces chronic ER stress, hence increasing baseline autophagy and promoting chemoresistance. The attenuation of ER stress restores basal autophagic activity and resensitizes melanoma cells to apoptosis.
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spelling pubmed-49053142016-06-15 Fateful music from a talented orchestra with a wicked conductor: Connection between oncogenic BRAF, ER stress, and autophagy in human melanoma Giglio, Paola Fimia, Gian Maria Lovat, Penny E Piacentini, Mauro Corazzari, Marco Mol Cell Oncol Author's Views Autophagy and endoplasmic reticulum (ER) stress are involved in the development, progression, and chemoresistance of melanoma. We recently reported that oncogenic serine/threonine-protein kinase BRAF induces chronic ER stress, hence increasing baseline autophagy and promoting chemoresistance. The attenuation of ER stress restores basal autophagic activity and resensitizes melanoma cells to apoptosis. Taylor & Francis 2015-01-26 /pmc/articles/PMC4905314/ /pubmed/27308477 http://dx.doi.org/10.4161/23723556.2014.995016 Text en © 2015 The Author(s). Published with license by Taylor & Francis Group, LLC http://creativecommons.org/licenses/by-nc/3.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution-Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/), which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. The moral rights of the named author(s) have been asserted.
spellingShingle Author's Views
Giglio, Paola
Fimia, Gian Maria
Lovat, Penny E
Piacentini, Mauro
Corazzari, Marco
Fateful music from a talented orchestra with a wicked conductor: Connection between oncogenic BRAF, ER stress, and autophagy in human melanoma
title Fateful music from a talented orchestra with a wicked conductor: Connection between oncogenic BRAF, ER stress, and autophagy in human melanoma
title_full Fateful music from a talented orchestra with a wicked conductor: Connection between oncogenic BRAF, ER stress, and autophagy in human melanoma
title_fullStr Fateful music from a talented orchestra with a wicked conductor: Connection between oncogenic BRAF, ER stress, and autophagy in human melanoma
title_full_unstemmed Fateful music from a talented orchestra with a wicked conductor: Connection between oncogenic BRAF, ER stress, and autophagy in human melanoma
title_short Fateful music from a talented orchestra with a wicked conductor: Connection between oncogenic BRAF, ER stress, and autophagy in human melanoma
title_sort fateful music from a talented orchestra with a wicked conductor: connection between oncogenic braf, er stress, and autophagy in human melanoma
topic Author's Views
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4905314/
https://www.ncbi.nlm.nih.gov/pubmed/27308477
http://dx.doi.org/10.4161/23723556.2014.995016
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