Disrupting the endothelin and Wnt relationship to overcome chemoresistance

Knowledge of the mechanisms underlying chemoresistance is important in the development of novel targeted treatments for ovarian cancer. We recently reported that targeting endothelin A receptor/β-arrestin-1, a binding partner of Wnt/β-catenin, is sufficient to sensitize ovarian cancer to chemotherap...

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Detalles Bibliográficos
Autores principales: Rosanò, Laura, Bagnato, Anna
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2015
Materias:
Author's Views
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4905315/
https://www.ncbi.nlm.nih.gov/pubmed/27308478
http://dx.doi.org/10.4161/23723556.2014.995025
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author Rosanò, Laura
Bagnato, Anna
author_facet Rosanò, Laura
Bagnato, Anna
author_sort Rosanò, Laura
collection PubMed
description Knowledge of the mechanisms underlying chemoresistance is important in the development of novel targeted treatments for ovarian cancer. We recently reported that targeting endothelin A receptor/β-arrestin-1, a binding partner of Wnt/β-catenin, is sufficient to sensitize ovarian cancer to chemotherapy. This result highlights endothelin-1 receptor antagonists as potential anticancer therapeutics.
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spelling pubmed-49053152016-06-15 Disrupting the endothelin and Wnt relationship to overcome chemoresistance Rosanò, Laura Bagnato, Anna Mol Cell Oncol Author's Views Knowledge of the mechanisms underlying chemoresistance is important in the development of novel targeted treatments for ovarian cancer. We recently reported that targeting endothelin A receptor/β-arrestin-1, a binding partner of Wnt/β-catenin, is sufficient to sensitize ovarian cancer to chemotherapy. This result highlights endothelin-1 receptor antagonists as potential anticancer therapeutics. Taylor & Francis 2015-01-30 /pmc/articles/PMC4905315/ /pubmed/27308478 http://dx.doi.org/10.4161/23723556.2014.995025 Text en © 2015 The Author(s). Published with license by Taylor & Francis Group, LLC Open Access CC BY NC http://creativecommons.org/licenses/by-nc/3.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution-Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/), which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. The moral rights of the named author(s) have been asserted.
spellingShingle Author's Views
Rosanò, Laura
Bagnato, Anna
Disrupting the endothelin and Wnt relationship to overcome chemoresistance
title Disrupting the endothelin and Wnt relationship to overcome chemoresistance
title_full Disrupting the endothelin and Wnt relationship to overcome chemoresistance
title_fullStr Disrupting the endothelin and Wnt relationship to overcome chemoresistance
title_full_unstemmed Disrupting the endothelin and Wnt relationship to overcome chemoresistance
title_short Disrupting the endothelin and Wnt relationship to overcome chemoresistance
title_sort disrupting the endothelin and wnt relationship to overcome chemoresistance
topic Author's Views
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4905315/
https://www.ncbi.nlm.nih.gov/pubmed/27308478
http://dx.doi.org/10.4161/23723556.2014.995025
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