The great migration of Bax and Bak

The Bcl-2 proteins Bcl-2-associated X protein (Bax) and Bcl-2 antagonist killer 1 (Bak) can commit cells to apoptosis. Retrotranslocation of Bax from the mitochondria into the cytosol is essential for cell survival. Recently, we reported that Bak is also present in the cytosol of healthy cells and t...

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Detalles Bibliográficos
Autor principal: Edlich, Frank
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2015
Materias:
Author's Views
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4905316/
https://www.ncbi.nlm.nih.gov/pubmed/27308479
http://dx.doi.org/10.4161/23723556.2014.995029
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author Edlich, Frank
author_facet Edlich, Frank
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description The Bcl-2 proteins Bcl-2-associated X protein (Bax) and Bcl-2 antagonist killer 1 (Bak) can commit cells to apoptosis. Retrotranslocation of Bax from the mitochondria into the cytosol is essential for cell survival. Recently, we reported that Bak is also present in the cytosol of healthy cells and that Bax and Bak are regulated by the same retrotranslocation process.
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spelling pubmed-49053162016-06-15 The great migration of Bax and Bak Edlich, Frank Mol Cell Oncol Author's Views The Bcl-2 proteins Bcl-2-associated X protein (Bax) and Bcl-2 antagonist killer 1 (Bak) can commit cells to apoptosis. Retrotranslocation of Bax from the mitochondria into the cytosol is essential for cell survival. Recently, we reported that Bak is also present in the cytosol of healthy cells and that Bax and Bak are regulated by the same retrotranslocation process. Taylor & Francis 2015-01-23 /pmc/articles/PMC4905316/ /pubmed/27308479 http://dx.doi.org/10.4161/23723556.2014.995029 Text en © 2015 The Author(s). Published with license by Taylor & Francis Group, LLC http://creativecommons.org/licenses/by-nc/3.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution-Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/), which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. The moral rights of the named author(s) have been asserted.
spellingShingle Author's Views
Edlich, Frank
The great migration of Bax and Bak
title The great migration of Bax and Bak
title_full The great migration of Bax and Bak
title_fullStr The great migration of Bax and Bak
title_full_unstemmed The great migration of Bax and Bak
title_short The great migration of Bax and Bak
title_sort great migration of bax and bak
topic Author's Views
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4905316/
https://www.ncbi.nlm.nih.gov/pubmed/27308479
http://dx.doi.org/10.4161/23723556.2014.995029
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