Cargando…
Fbw7 and Usp28 – enemies and allies
The Usp28 deubiquitinase antagonizes Fbw7-mediated turnover of multiple oncoproteins, including Myc, Jun, and Notch, and promotes tumorigenesis in the intestine. Our recent study reveals that Usp28 also counteracts autocatalytic ubiquitination of Fbw7, suggesting a complex role for Usp28 in the regu...
Autores principales: | , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Taylor & Francis
2015
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4905318/ https://www.ncbi.nlm.nih.gov/pubmed/27308481 http://dx.doi.org/10.4161/23723556.2014.995041 |
_version_ | 1782437246792630272 |
---|---|
author | Taranets, Lyudmyla Zhu, Jing Xu, Wenshan Popov, Nikita |
author_facet | Taranets, Lyudmyla Zhu, Jing Xu, Wenshan Popov, Nikita |
author_sort | Taranets, Lyudmyla |
collection | PubMed |
description | The Usp28 deubiquitinase antagonizes Fbw7-mediated turnover of multiple oncoproteins, including Myc, Jun, and Notch, and promotes tumorigenesis in the intestine. Our recent study reveals that Usp28 also counteracts autocatalytic ubiquitination of Fbw7, suggesting a complex role for Usp28 in the regulation of Fbw7 activity and tumor development. |
format | Online Article Text |
id | pubmed-4905318 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2015 |
publisher | Taylor & Francis |
record_format | MEDLINE/PubMed |
spelling | pubmed-49053182016-06-15 Fbw7 and Usp28 – enemies and allies Taranets, Lyudmyla Zhu, Jing Xu, Wenshan Popov, Nikita Mol Cell Oncol Author's Views The Usp28 deubiquitinase antagonizes Fbw7-mediated turnover of multiple oncoproteins, including Myc, Jun, and Notch, and promotes tumorigenesis in the intestine. Our recent study reveals that Usp28 also counteracts autocatalytic ubiquitination of Fbw7, suggesting a complex role for Usp28 in the regulation of Fbw7 activity and tumor development. Taylor & Francis 2015-01-23 /pmc/articles/PMC4905318/ /pubmed/27308481 http://dx.doi.org/10.4161/23723556.2014.995041 Text en © 2015 The Author(s). Published with license by Taylor & Francis Group, LLC http://creativecommons.org/licenses/by-nc/3.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution-Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/), which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. The moral rights of the named author(s) have been asserted. |
spellingShingle | Author's Views Taranets, Lyudmyla Zhu, Jing Xu, Wenshan Popov, Nikita Fbw7 and Usp28 – enemies and allies |
title | Fbw7 and Usp28 – enemies and allies |
title_full | Fbw7 and Usp28 – enemies and allies |
title_fullStr | Fbw7 and Usp28 – enemies and allies |
title_full_unstemmed | Fbw7 and Usp28 – enemies and allies |
title_short | Fbw7 and Usp28 – enemies and allies |
title_sort | fbw7 and usp28 – enemies and allies |
topic | Author's Views |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4905318/ https://www.ncbi.nlm.nih.gov/pubmed/27308481 http://dx.doi.org/10.4161/23723556.2014.995041 |
work_keys_str_mv | AT taranetslyudmyla fbw7andusp28enemiesandallies AT zhujing fbw7andusp28enemiesandallies AT xuwenshan fbw7andusp28enemiesandallies AT popovnikita fbw7andusp28enemiesandallies |