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Fbw7 and Usp28 – enemies and allies

The Usp28 deubiquitinase antagonizes Fbw7-mediated turnover of multiple oncoproteins, including Myc, Jun, and Notch, and promotes tumorigenesis in the intestine. Our recent study reveals that Usp28 also counteracts autocatalytic ubiquitination of Fbw7, suggesting a complex role for Usp28 in the regu...

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Detalles Bibliográficos
Autores principales: Taranets, Lyudmyla, Zhu, Jing, Xu, Wenshan, Popov, Nikita
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4905318/
https://www.ncbi.nlm.nih.gov/pubmed/27308481
http://dx.doi.org/10.4161/23723556.2014.995041
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author Taranets, Lyudmyla
Zhu, Jing
Xu, Wenshan
Popov, Nikita
author_facet Taranets, Lyudmyla
Zhu, Jing
Xu, Wenshan
Popov, Nikita
author_sort Taranets, Lyudmyla
collection PubMed
description The Usp28 deubiquitinase antagonizes Fbw7-mediated turnover of multiple oncoproteins, including Myc, Jun, and Notch, and promotes tumorigenesis in the intestine. Our recent study reveals that Usp28 also counteracts autocatalytic ubiquitination of Fbw7, suggesting a complex role for Usp28 in the regulation of Fbw7 activity and tumor development.
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spelling pubmed-49053182016-06-15 Fbw7 and Usp28 – enemies and allies Taranets, Lyudmyla Zhu, Jing Xu, Wenshan Popov, Nikita Mol Cell Oncol Author's Views The Usp28 deubiquitinase antagonizes Fbw7-mediated turnover of multiple oncoproteins, including Myc, Jun, and Notch, and promotes tumorigenesis in the intestine. Our recent study reveals that Usp28 also counteracts autocatalytic ubiquitination of Fbw7, suggesting a complex role for Usp28 in the regulation of Fbw7 activity and tumor development. Taylor & Francis 2015-01-23 /pmc/articles/PMC4905318/ /pubmed/27308481 http://dx.doi.org/10.4161/23723556.2014.995041 Text en © 2015 The Author(s). Published with license by Taylor & Francis Group, LLC http://creativecommons.org/licenses/by-nc/3.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution-Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/), which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. The moral rights of the named author(s) have been asserted.
spellingShingle Author's Views
Taranets, Lyudmyla
Zhu, Jing
Xu, Wenshan
Popov, Nikita
Fbw7 and Usp28 – enemies and allies
title Fbw7 and Usp28 – enemies and allies
title_full Fbw7 and Usp28 – enemies and allies
title_fullStr Fbw7 and Usp28 – enemies and allies
title_full_unstemmed Fbw7 and Usp28 – enemies and allies
title_short Fbw7 and Usp28 – enemies and allies
title_sort fbw7 and usp28 – enemies and allies
topic Author's Views
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4905318/
https://www.ncbi.nlm.nih.gov/pubmed/27308481
http://dx.doi.org/10.4161/23723556.2014.995041
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