Activated Acinus boosts basal autophagy

Acinus (Acn) is a nuclear protein that participates in the regulation of autophagy. Loss of Acn function prevents autophagy in starving cells. Conversely, Acn activation induces basal autophagy. This enhances the quality control functions of autophagy such as the removal of misfolded proteins, there...

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Detalles Bibliográficos
Autores principales: Nandi, Nilay, Tyra, Lauren K, Krämer, Helmut
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2015
Materias:
Commentary
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4905319/
https://www.ncbi.nlm.nih.gov/pubmed/27308482
http://dx.doi.org/10.4161/23723556.2014.995043
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author Nandi, Nilay
Tyra, Lauren K
Krämer, Helmut
author_facet Nandi, Nilay
Tyra, Lauren K
Krämer, Helmut
author_sort Nandi, Nilay
collection PubMed
description Acinus (Acn) is a nuclear protein that participates in the regulation of autophagy. Loss of Acn function prevents autophagy in starving cells. Conversely, Acn activation induces basal autophagy. This enhances the quality control functions of autophagy such as the removal of misfolded proteins, thereby reducing neurodegeneration and prolonging lifespan. Acn activity is enhanced by Akt1-mediated phosphorylation, which counteracts the cleavage of Acn by a caspase-3 homolog.
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spelling pubmed-49053192016-06-15 Activated Acinus boosts basal autophagy Nandi, Nilay Tyra, Lauren K Krämer, Helmut Mol Cell Oncol Commentary Acinus (Acn) is a nuclear protein that participates in the regulation of autophagy. Loss of Acn function prevents autophagy in starving cells. Conversely, Acn activation induces basal autophagy. This enhances the quality control functions of autophagy such as the removal of misfolded proteins, thereby reducing neurodegeneration and prolonging lifespan. Acn activity is enhanced by Akt1-mediated phosphorylation, which counteracts the cleavage of Acn by a caspase-3 homolog. Taylor & Francis 2015-01-23 /pmc/articles/PMC4905319/ /pubmed/27308482 http://dx.doi.org/10.4161/23723556.2014.995043 Text en © 2015 The Author(s). Published with license by Taylor & Francis Group, LLC http://creativecommons.org/licenses/by/3.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. The moral rights of the named author(s) have been asserted.
spellingShingle Commentary
Nandi, Nilay
Tyra, Lauren K
Krämer, Helmut
Activated Acinus boosts basal autophagy
title Activated Acinus boosts basal autophagy
title_full Activated Acinus boosts basal autophagy
title_fullStr Activated Acinus boosts basal autophagy
title_full_unstemmed Activated Acinus boosts basal autophagy
title_short Activated Acinus boosts basal autophagy
title_sort activated acinus boosts basal autophagy
topic Commentary
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4905319/
https://www.ncbi.nlm.nih.gov/pubmed/27308482
http://dx.doi.org/10.4161/23723556.2014.995043
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