CD44 regulates Wnt signaling at the level of LRP6

CD44 was recently identified as a positive feedback regulator of Wnt/β-catenin signaling. This regulation occurs at the level of low-density lipoprotein receptor-related protein 6 phosphorylation and membrane targeting. These findings broaden our understanding of the Wnt pathway activation process a...

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Detalles Bibliográficos
Autores principales: Orian-Rousseau, Véronique, Schmitt, Mark
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2015
Materias:
Author's Views
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4905321/
https://www.ncbi.nlm.nih.gov/pubmed/27308483
http://dx.doi.org/10.4161/23723556.2014.995046
Descripción
Sumario:CD44 was recently identified as a positive feedback regulator of Wnt/β-catenin signaling. This regulation occurs at the level of low-density lipoprotein receptor-related protein 6 phosphorylation and membrane targeting. These findings broaden our understanding of the Wnt pathway activation process and open new perspectives for anti-CD44 therapies in diseases associated with Wnt induction, including colorectal cancer.

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