CD44 regulates Wnt signaling at the level of LRP6

CD44 was recently identified as a positive feedback regulator of Wnt/β-catenin signaling. This regulation occurs at the level of low-density lipoprotein receptor-related protein 6 phosphorylation and membrane targeting. These findings broaden our understanding of the Wnt pathway activation process a...

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Detalles Bibliográficos
Autores principales: Orian-Rousseau, Véronique, Schmitt, Mark
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2015
Materias:
Author's Views
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4905321/
https://www.ncbi.nlm.nih.gov/pubmed/27308483
http://dx.doi.org/10.4161/23723556.2014.995046
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author Orian-Rousseau, Véronique
Schmitt, Mark
author_facet Orian-Rousseau, Véronique
Schmitt, Mark
author_sort Orian-Rousseau, Véronique
collection PubMed
description CD44 was recently identified as a positive feedback regulator of Wnt/β-catenin signaling. This regulation occurs at the level of low-density lipoprotein receptor-related protein 6 phosphorylation and membrane targeting. These findings broaden our understanding of the Wnt pathway activation process and open new perspectives for anti-CD44 therapies in diseases associated with Wnt induction, including colorectal cancer.
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spelling pubmed-49053212016-06-15 CD44 regulates Wnt signaling at the level of LRP6 Orian-Rousseau, Véronique Schmitt, Mark Mol Cell Oncol Author's Views CD44 was recently identified as a positive feedback regulator of Wnt/β-catenin signaling. This regulation occurs at the level of low-density lipoprotein receptor-related protein 6 phosphorylation and membrane targeting. These findings broaden our understanding of the Wnt pathway activation process and open new perspectives for anti-CD44 therapies in diseases associated with Wnt induction, including colorectal cancer. Taylor & Francis 2015-01-23 /pmc/articles/PMC4905321/ /pubmed/27308483 http://dx.doi.org/10.4161/23723556.2014.995046 Text en © 2015 The Author(s). Published with license by Taylor & Francis Group, LLC http://creativecommons.org/licenses/by-nc/3.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution-Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/), which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. The moral rights of the named author(s) have been asserted.
spellingShingle Author's Views
Orian-Rousseau, Véronique
Schmitt, Mark
CD44 regulates Wnt signaling at the level of LRP6
title CD44 regulates Wnt signaling at the level of LRP6
title_full CD44 regulates Wnt signaling at the level of LRP6
title_fullStr CD44 regulates Wnt signaling at the level of LRP6
title_full_unstemmed CD44 regulates Wnt signaling at the level of LRP6
title_short CD44 regulates Wnt signaling at the level of LRP6
title_sort cd44 regulates wnt signaling at the level of lrp6
topic Author's Views
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4905321/
https://www.ncbi.nlm.nih.gov/pubmed/27308483
http://dx.doi.org/10.4161/23723556.2014.995046
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