The mitosis-differentiation checkpoint, another guardian of the epidermal genome

The role of p53, the original “guardian of the genome”, in skin has remained elusive. We have explored p53 function in human epidermal cells and demonstrated the importance of a mitosis-differentiation checkpoint to suppress potentially precancerous cells. This model places epidermal endoreplication...

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Autores principales: Gandarillas, Alberto, Molinuevo, Rut, Freije, Ana, Alonso-Lecue, Pilar
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2015
Materias:
Author's Views
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4905324/
https://www.ncbi.nlm.nih.gov/pubmed/27308487
http://dx.doi.org/10.1080/23723556.2014.997127
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author Gandarillas, Alberto
Molinuevo, Rut
Freije, Ana
Alonso-Lecue, Pilar
author_facet Gandarillas, Alberto
Molinuevo, Rut
Freije, Ana
Alonso-Lecue, Pilar
author_sort Gandarillas, Alberto
collection PubMed
description The role of p53, the original “guardian of the genome”, in skin has remained elusive. We have explored p53 function in human epidermal cells and demonstrated the importance of a mitosis-differentiation checkpoint to suppress potentially precancerous cells. This model places epidermal endoreplication as an antioncogenic mechanism in the face of irreparable genetic alterations.
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spelling pubmed-49053242016-06-15 The mitosis-differentiation checkpoint, another guardian of the epidermal genome Gandarillas, Alberto Molinuevo, Rut Freije, Ana Alonso-Lecue, Pilar Mol Cell Oncol Author's Views The role of p53, the original “guardian of the genome”, in skin has remained elusive. We have explored p53 function in human epidermal cells and demonstrated the importance of a mitosis-differentiation checkpoint to suppress potentially precancerous cells. This model places epidermal endoreplication as an antioncogenic mechanism in the face of irreparable genetic alterations. Taylor & Francis 2015-01-21 /pmc/articles/PMC4905324/ /pubmed/27308487 http://dx.doi.org/10.1080/23723556.2014.997127 Text en © 2015 The Author(s). Published with license by Taylor & Francis Group, LLC http://creativecommons.org/licenses/by-nc/3.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution-Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/), which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. The moral rights of the named author(s) have been asserted.
spellingShingle Author's Views
Gandarillas, Alberto
Molinuevo, Rut
Freije, Ana
Alonso-Lecue, Pilar
The mitosis-differentiation checkpoint, another guardian of the epidermal genome
title The mitosis-differentiation checkpoint, another guardian of the epidermal genome
title_full The mitosis-differentiation checkpoint, another guardian of the epidermal genome
title_fullStr The mitosis-differentiation checkpoint, another guardian of the epidermal genome
title_full_unstemmed The mitosis-differentiation checkpoint, another guardian of the epidermal genome
title_short The mitosis-differentiation checkpoint, another guardian of the epidermal genome
title_sort mitosis-differentiation checkpoint, another guardian of the epidermal genome
topic Author's Views
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4905324/
https://www.ncbi.nlm.nih.gov/pubmed/27308487
http://dx.doi.org/10.1080/23723556.2014.997127
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