The ubiquitin ligase APC/C(Cdh1) puts the brakes on DNA-end resection

DNA double-strand breaks (DSBs) are highly deleterious lesions and their misrepair can promote genomic instability, a hallmark of cancer. DNA-end resection is a cell cycle-regulated mechanism that is required for the faithful repair of DSBs. We recently discovered that the anaphase-promoting complex...

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Detalles Bibliográficos
Autores principales: Lafranchi, Lorenzo, Sartori, Alessandro A
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2015
Materias:
Author's View
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4905325/
https://www.ncbi.nlm.nih.gov/pubmed/27308488
http://dx.doi.org/10.1080/23723556.2014.1000696
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author Lafranchi, Lorenzo
Sartori, Alessandro A
author_facet Lafranchi, Lorenzo
Sartori, Alessandro A
author_sort Lafranchi, Lorenzo
collection PubMed
description DNA double-strand breaks (DSBs) are highly deleterious lesions and their misrepair can promote genomic instability, a hallmark of cancer. DNA-end resection is a cell cycle-regulated mechanism that is required for the faithful repair of DSBs. We recently discovered that the anaphase-promoting complex/cyclosome-Cdh1 (APC/C(Cdh1)) ubiquitin ligase is responsible for the timely degradation of CtBP-interacting protein (CtIP), a key DNA-end resection factor, providing a new layer of regulation of DSB repair in human cells.
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spelling pubmed-49053252016-06-15 The ubiquitin ligase APC/C(Cdh1) puts the brakes on DNA-end resection Lafranchi, Lorenzo Sartori, Alessandro A Mol Cell Oncol Author's View DNA double-strand breaks (DSBs) are highly deleterious lesions and their misrepair can promote genomic instability, a hallmark of cancer. DNA-end resection is a cell cycle-regulated mechanism that is required for the faithful repair of DSBs. We recently discovered that the anaphase-promoting complex/cyclosome-Cdh1 (APC/C(Cdh1)) ubiquitin ligase is responsible for the timely degradation of CtBP-interacting protein (CtIP), a key DNA-end resection factor, providing a new layer of regulation of DSB repair in human cells. Taylor & Francis 2015-01-23 /pmc/articles/PMC4905325/ /pubmed/27308488 http://dx.doi.org/10.1080/23723556.2014.1000696 Text en © 2015 The Author(s). Published with license by Taylor & Francis Group, LLC http://creativecommons.org/licenses/by-nc/3.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution-Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/), which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. The moral rights of the named author(s) have been asserted.
spellingShingle Author's View
Lafranchi, Lorenzo
Sartori, Alessandro A
The ubiquitin ligase APC/C(Cdh1) puts the brakes on DNA-end resection
title The ubiquitin ligase APC/C(Cdh1) puts the brakes on DNA-end resection
title_full The ubiquitin ligase APC/C(Cdh1) puts the brakes on DNA-end resection
title_fullStr The ubiquitin ligase APC/C(Cdh1) puts the brakes on DNA-end resection
title_full_unstemmed The ubiquitin ligase APC/C(Cdh1) puts the brakes on DNA-end resection
title_short The ubiquitin ligase APC/C(Cdh1) puts the brakes on DNA-end resection
title_sort ubiquitin ligase apc/c(cdh1) puts the brakes on dna-end resection
topic Author's View
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4905325/
https://www.ncbi.nlm.nih.gov/pubmed/27308488
http://dx.doi.org/10.1080/23723556.2014.1000696
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