Cargando…
The ubiquitin ligase APC/C(Cdh1) puts the brakes on DNA-end resection
DNA double-strand breaks (DSBs) are highly deleterious lesions and their misrepair can promote genomic instability, a hallmark of cancer. DNA-end resection is a cell cycle-regulated mechanism that is required for the faithful repair of DSBs. We recently discovered that the anaphase-promoting complex...
| Autores principales: | , |
|---|---|
| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Taylor & Francis
2015
|
| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4905325/ https://www.ncbi.nlm.nih.gov/pubmed/27308488 http://dx.doi.org/10.1080/23723556.2014.1000696 |