Redox regulation of Smac mimetic-induced cell death

Cell death and survival programs are controlled by the cellular redox state, which is typically dysregulated during oncogenesis. A recent study reports that the inhibition of antioxidant defenses resulting from glutathione depletion can prime acute lymphoblastic leukemia cells for death induced by S...

Descripción completa

Detalles Bibliográficos
Autor principal: Fulda, Simone
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2015
Materias:
Commentary
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4905326/
https://www.ncbi.nlm.nih.gov/pubmed/27308489
http://dx.doi.org/10.1080/23723556.2014.1000697
_version_ 1782437248171507712
author Fulda, Simone
author_facet Fulda, Simone
author_sort Fulda, Simone
collection PubMed
description Cell death and survival programs are controlled by the cellular redox state, which is typically dysregulated during oncogenesis. A recent study reports that the inhibition of antioxidant defenses resulting from glutathione depletion can prime acute lymphoblastic leukemia cells for death induced by Smac mimetics.
format Online
Article
Text
id pubmed-4905326
institution National Center for Biotechnology Information
language English
publishDate 2015
publisher Taylor & Francis
record_format MEDLINE/PubMed
spelling pubmed-49053262016-06-15 Redox regulation of Smac mimetic-induced cell death Fulda, Simone Mol Cell Oncol Commentary Cell death and survival programs are controlled by the cellular redox state, which is typically dysregulated during oncogenesis. A recent study reports that the inhibition of antioxidant defenses resulting from glutathione depletion can prime acute lymphoblastic leukemia cells for death induced by Smac mimetics. Taylor & Francis 2015-01-23 /pmc/articles/PMC4905326/ /pubmed/27308489 http://dx.doi.org/10.1080/23723556.2014.1000697 Text en © 2015 The Author(s). Published with license by Taylor & Francis Group, LLC http://creativecommons.org/licenses/by-nc/3.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution-Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/), which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. The moral rights of the named author(s) have been asserted.
spellingShingle Commentary
Fulda, Simone
Redox regulation of Smac mimetic-induced cell death
title Redox regulation of Smac mimetic-induced cell death
title_full Redox regulation of Smac mimetic-induced cell death
title_fullStr Redox regulation of Smac mimetic-induced cell death
title_full_unstemmed Redox regulation of Smac mimetic-induced cell death
title_short Redox regulation of Smac mimetic-induced cell death
title_sort redox regulation of smac mimetic-induced cell death
topic Commentary
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4905326/
https://www.ncbi.nlm.nih.gov/pubmed/27308489
http://dx.doi.org/10.1080/23723556.2014.1000697
work_keys_str_mv AT fuldasimone redoxregulationofsmacmimeticinducedcelldeath

Ejemplares similares