Mirror image phosphoinositides regulate autophagy

Autophagosome formation is stimulated by canonical VPS34-dependent formation of phosphatidylinositol 3-phosphate [PI(3)P], which recruits effectors such as WIPI2. However, non-canonical VPS34-independent autophagy has also been proposed. We recently described that PI(5)P regulates autophagosome biog...

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Detalles Bibliográficos
Autores principales: Vicinanza, Mariella, Rubinsztein, David C
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2015
Materias:
Author's View
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4905334/
https://www.ncbi.nlm.nih.gov/pubmed/27308581
http://dx.doi.org/10.1080/23723556.2015.1019974
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author Vicinanza, Mariella
Rubinsztein, David C
author_facet Vicinanza, Mariella
Rubinsztein, David C
author_sort Vicinanza, Mariella
collection PubMed
description Autophagosome formation is stimulated by canonical VPS34-dependent formation of phosphatidylinositol 3-phosphate [PI(3)P], which recruits effectors such as WIPI2. However, non-canonical VPS34-independent autophagy has also been proposed. We recently described that PI(5)P regulates autophagosome biogenesis, recruits WIPI2, and rescues autophagy in VPS34-inactivated cells. These alternative autophagy-initiating pathways reveal new druggable targets for treating neurodegeneration and cancer.
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spelling pubmed-49053342016-06-15 Mirror image phosphoinositides regulate autophagy Vicinanza, Mariella Rubinsztein, David C Mol Cell Oncol Author's View Autophagosome formation is stimulated by canonical VPS34-dependent formation of phosphatidylinositol 3-phosphate [PI(3)P], which recruits effectors such as WIPI2. However, non-canonical VPS34-independent autophagy has also been proposed. We recently described that PI(5)P regulates autophagosome biogenesis, recruits WIPI2, and rescues autophagy in VPS34-inactivated cells. These alternative autophagy-initiating pathways reveal new druggable targets for treating neurodegeneration and cancer. Taylor & Francis 2015-02-26 /pmc/articles/PMC4905334/ /pubmed/27308581 http://dx.doi.org/10.1080/23723556.2015.1019974 Text en © 2016 The Author(s). Published with license by Taylor & Francis http://creativecommons.org/licenses/by/3.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. The moral rights of the named author(s) have been asserted.
spellingShingle Author's View
Vicinanza, Mariella
Rubinsztein, David C
Mirror image phosphoinositides regulate autophagy
title Mirror image phosphoinositides regulate autophagy
title_full Mirror image phosphoinositides regulate autophagy
title_fullStr Mirror image phosphoinositides regulate autophagy
title_full_unstemmed Mirror image phosphoinositides regulate autophagy
title_short Mirror image phosphoinositides regulate autophagy
title_sort mirror image phosphoinositides regulate autophagy
topic Author's View
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4905334/
https://www.ncbi.nlm.nih.gov/pubmed/27308581
http://dx.doi.org/10.1080/23723556.2015.1019974
work_keys_str_mv AT vicinanzamariella mirrorimagephosphoinositidesregulateautophagy
AT rubinszteindavidc mirrorimagephosphoinositidesregulateautophagy

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