The BARD1/HP1 interaction: Another clue to heterochromatin involvement in homologous recombination

Chromatin compaction represents a barrier for the repair of DNA double-strand breaks (DSBs). However, heterochromatin components are also required for DSB repair by homologous recombination. The BARD1/HP1 interaction, required for the retention of BRCA1, CTIP, and RAD51 at DSB sites, may play a crit...

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Detalles Bibliográficos
Autores principales: Fukuda, Takayo, Tsuruga, Tomoko, Kuroda, Takako, Takeuchi, Jun, Wu, Wenwen, Ohta, Tomohiko
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2015
Materias:
Author's View
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4905335/
https://www.ncbi.nlm.nih.gov/pubmed/27308582
http://dx.doi.org/10.1080/23723556.2015.1030535
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author Fukuda, Takayo
Tsuruga, Tomoko
Kuroda, Takako
Takeuchi, Jun
Wu, Wenwen
Ohta, Tomohiko
author_facet Fukuda, Takayo
Tsuruga, Tomoko
Kuroda, Takako
Takeuchi, Jun
Wu, Wenwen
Ohta, Tomohiko
author_sort Fukuda, Takayo
collection PubMed
description Chromatin compaction represents a barrier for the repair of DNA double-strand breaks (DSBs). However, heterochromatin components are also required for DSB repair by homologous recombination. The BARD1/HP1 interaction, required for the retention of BRCA1, CTIP, and RAD51 at DSB sites, may play a critical role in the crosstalk between chromatin compaction and DSB repair.
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spelling pubmed-49053352016-06-15 The BARD1/HP1 interaction: Another clue to heterochromatin involvement in homologous recombination Fukuda, Takayo Tsuruga, Tomoko Kuroda, Takako Takeuchi, Jun Wu, Wenwen Ohta, Tomohiko Mol Cell Oncol Author's View Chromatin compaction represents a barrier for the repair of DNA double-strand breaks (DSBs). However, heterochromatin components are also required for DSB repair by homologous recombination. The BARD1/HP1 interaction, required for the retention of BRCA1, CTIP, and RAD51 at DSB sites, may play a critical role in the crosstalk between chromatin compaction and DSB repair. Taylor & Francis 2015-04-14 /pmc/articles/PMC4905335/ /pubmed/27308582 http://dx.doi.org/10.1080/23723556.2015.1030535 Text en © 2016 The Author(s). Published with license by Taylor & Francis Group, LLC http://creativecommons.org/licenses/by-nc/3.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution-Non-Commercial License http://creativecommons.org/licenses/by-nc/3.0/, which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. The moral rights of the named author(s) have been asserted.
spellingShingle Author's View
Fukuda, Takayo
Tsuruga, Tomoko
Kuroda, Takako
Takeuchi, Jun
Wu, Wenwen
Ohta, Tomohiko
The BARD1/HP1 interaction: Another clue to heterochromatin involvement in homologous recombination
title The BARD1/HP1 interaction: Another clue to heterochromatin involvement in homologous recombination
title_full The BARD1/HP1 interaction: Another clue to heterochromatin involvement in homologous recombination
title_fullStr The BARD1/HP1 interaction: Another clue to heterochromatin involvement in homologous recombination
title_full_unstemmed The BARD1/HP1 interaction: Another clue to heterochromatin involvement in homologous recombination
title_short The BARD1/HP1 interaction: Another clue to heterochromatin involvement in homologous recombination
title_sort bard1/hp1 interaction: another clue to heterochromatin involvement in homologous recombination
topic Author's View
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4905335/
https://www.ncbi.nlm.nih.gov/pubmed/27308582
http://dx.doi.org/10.1080/23723556.2015.1030535
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