Regulation of autophagy by two products of one gene: TRPM3 and miR-204

In clear cell renal cell carcinoma (ccRCC), oncogenic autophagy dependent on microtubule-associated protein 1 light chain 3 α and β (LC3A and LC3B) is stimulated by activity of the transient receptor potential melastatin 3 (TRPM3) channel through multiple complementary mechanisms. The Von Hippel-Lin...

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Autores principales: Cost, Nicolas G, Czyzyk-Krzeska, Maria F
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2015
Materias:
Author's View
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4905337/
https://www.ncbi.nlm.nih.gov/pubmed/27308495
http://dx.doi.org/10.1080/23723556.2014.1002712
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author Cost, Nicolas G
Czyzyk-Krzeska, Maria F
author_facet Cost, Nicolas G
Czyzyk-Krzeska, Maria F
author_sort Cost, Nicolas G
collection PubMed
description In clear cell renal cell carcinoma (ccRCC), oncogenic autophagy dependent on microtubule-associated protein 1 light chain 3 α and β (LC3A and LC3B) is stimulated by activity of the transient receptor potential melastatin 3 (TRPM3) channel through multiple complementary mechanisms. The Von Hippel-Lindau (VHL) tumor suppressor represses this oncogenic autophagy in a coordinated manner through the activity of miR-204, which is expressed from intron 6 of the gene encoding TRPM3. TRPM3 represents an actionable target for ccRCC treatment.
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spelling pubmed-49053372016-06-15 Regulation of autophagy by two products of one gene: TRPM3 and miR-204 Cost, Nicolas G Czyzyk-Krzeska, Maria F Mol Cell Oncol Author's View In clear cell renal cell carcinoma (ccRCC), oncogenic autophagy dependent on microtubule-associated protein 1 light chain 3 α and β (LC3A and LC3B) is stimulated by activity of the transient receptor potential melastatin 3 (TRPM3) channel through multiple complementary mechanisms. The Von Hippel-Lindau (VHL) tumor suppressor represses this oncogenic autophagy in a coordinated manner through the activity of miR-204, which is expressed from intron 6 of the gene encoding TRPM3. TRPM3 represents an actionable target for ccRCC treatment. Taylor & Francis 2015-01-23 /pmc/articles/PMC4905337/ /pubmed/27308495 http://dx.doi.org/10.1080/23723556.2014.1002712 Text en © 2015 The Author(s). Published with license by Taylor & Francis Group, LLC http://creativecommons.org/licenses/by-nc/3.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution-Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/), which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. The moral rights of the named author(s) have been asserted.
spellingShingle Author's View
Cost, Nicolas G
Czyzyk-Krzeska, Maria F
Regulation of autophagy by two products of one gene: TRPM3 and miR-204
title Regulation of autophagy by two products of one gene: TRPM3 and miR-204
title_full Regulation of autophagy by two products of one gene: TRPM3 and miR-204
title_fullStr Regulation of autophagy by two products of one gene: TRPM3 and miR-204
title_full_unstemmed Regulation of autophagy by two products of one gene: TRPM3 and miR-204
title_short Regulation of autophagy by two products of one gene: TRPM3 and miR-204
title_sort regulation of autophagy by two products of one gene: trpm3 and mir-204
topic Author's View
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4905337/
https://www.ncbi.nlm.nih.gov/pubmed/27308495
http://dx.doi.org/10.1080/23723556.2014.1002712
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