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Suppression of ectopic assembly of centriole proteins ensures mitotic spindle integrity
Abnormalities in maintaining the appropriate number of centrioles could be the origin of genome instability in tumor formation. Recently, we demonstrated that ectopic formation of aberrant centriole-related structures occurs even in the presence of pre-existing centrioles, leading to mitotic spindle...
| Autores principales: | , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Taylor & Francis
2015
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4905339/ https://www.ncbi.nlm.nih.gov/pubmed/27308496 http://dx.doi.org/10.1080/23723556.2014.1002717 |
| Sumario: | Abnormalities in maintaining the appropriate number of centrioles could be the origin of genome instability in tumor formation. Recently, we demonstrated that ectopic formation of aberrant centriole-related structures occurs even in the presence of pre-existing centrioles, leading to mitotic spindle defects and possibly contributing to tumorigenesis. |
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