Type I collagen fibrils and discoidin domain receptor 1 set invadosomes straight

Accumulation of type I collagen fibrils in tumors is associated with an increased risk of metastasis. We recently demonstrated that the collagen sensor discoidin domain receptor 1 (DDR1) interacts with type I collagen fibrils to allow proteolysis-based cancer cell invasion through the formation of a...

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Detalles Bibliográficos
Autores principales: Moreau, Violaine, Saltel, Frédéric
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2015
Materias:
Author's View
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4905343/
https://www.ncbi.nlm.nih.gov/pubmed/27308500
http://dx.doi.org/10.1080/23723556.2015.1004963
Descripción
Sumario:Accumulation of type I collagen fibrils in tumors is associated with an increased risk of metastasis. We recently demonstrated that the collagen sensor discoidin domain receptor 1 (DDR1) interacts with type I collagen fibrils to allow proteolysis-based cancer cell invasion through the formation of a new class of invadosomes, termed linear invadosomes.

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