Caspase-2 and the oxidative stress response

Caspase-2, one of the earliest discovered caspases, has emerged as a multifunctional enzyme with roles that are not limited to cell death. It acts as a tumor suppressor, prevents genetic instability, and protects against aging by playing a crucial role in sensing alterations in cellular redox status...

Descripción completa

Detalles Bibliográficos
Autores principales: Shalini, Sonia, Kumar, Sharad
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2015
Materias:
Author's View
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4905344/
https://www.ncbi.nlm.nih.gov/pubmed/27308499
http://dx.doi.org/10.1080/23723556.2015.1004956
_version_ 1782437251129540608
author Shalini, Sonia
Kumar, Sharad
author_facet Shalini, Sonia
Kumar, Sharad
author_sort Shalini, Sonia
collection PubMed
description Caspase-2, one of the earliest discovered caspases, has emerged as a multifunctional enzyme with roles that are not limited to cell death. It acts as a tumor suppressor, prevents genetic instability, and protects against aging by playing a crucial role in sensing alterations in cellular redox status and activating the antioxidant defense system. These apparent non-apoptotic functions, only discovered recently, emphasize the importance of this often-neglected protease.
format Online
Article
Text
id pubmed-4905344
institution National Center for Biotechnology Information
language English
publishDate 2015
publisher Taylor & Francis
record_format MEDLINE/PubMed
spelling pubmed-49053442016-06-15 Caspase-2 and the oxidative stress response Shalini, Sonia Kumar, Sharad Mol Cell Oncol Author's View Caspase-2, one of the earliest discovered caspases, has emerged as a multifunctional enzyme with roles that are not limited to cell death. It acts as a tumor suppressor, prevents genetic instability, and protects against aging by playing a crucial role in sensing alterations in cellular redox status and activating the antioxidant defense system. These apparent non-apoptotic functions, only discovered recently, emphasize the importance of this often-neglected protease. Taylor & Francis 2015-01-23 /pmc/articles/PMC4905344/ /pubmed/27308499 http://dx.doi.org/10.1080/23723556.2015.1004956 Text en © 2015 The Author(s). Published with license by Taylor & Francis Group, LLC http://creativecommons.org/licenses/by-nc/3.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution-Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/), which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. The moral rights of the named author(s) have been asserted.
spellingShingle Author's View
Shalini, Sonia
Kumar, Sharad
Caspase-2 and the oxidative stress response
title Caspase-2 and the oxidative stress response
title_full Caspase-2 and the oxidative stress response
title_fullStr Caspase-2 and the oxidative stress response
title_full_unstemmed Caspase-2 and the oxidative stress response
title_short Caspase-2 and the oxidative stress response
title_sort caspase-2 and the oxidative stress response
topic Author's View
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4905344/
https://www.ncbi.nlm.nih.gov/pubmed/27308499
http://dx.doi.org/10.1080/23723556.2015.1004956
work_keys_str_mv AT shalinisonia caspase2andtheoxidativestressresponse
AT kumarsharad caspase2andtheoxidativestressresponse

Ejemplares similares