CHCHD2 connects mitochondrial metabolism to apoptosis

As the powerhouse of cells and gatekeeper for apoptosis, mitochondria control life and death. CHCHD2, a mitochondrial protein previously known to regulate metabolism, has recently been identified as an apoptosis inhibitor. New data suggest a model in which CHCHD2 performs a prosurvival function by a...

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Detalles Bibliográficos
Autores principales: Liu, Yong, Zhang, Yanping
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2015
Materias:
Author's Views
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4905345/
https://www.ncbi.nlm.nih.gov/pubmed/27308501
http://dx.doi.org/10.1080/23723556.2015.1004964
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author Liu, Yong
Zhang, Yanping
author_facet Liu, Yong
Zhang, Yanping
author_sort Liu, Yong
collection PubMed
description As the powerhouse of cells and gatekeeper for apoptosis, mitochondria control life and death. CHCHD2, a mitochondrial protein previously known to regulate metabolism, has recently been identified as an apoptosis inhibitor. New data suggest a model in which CHCHD2 performs a prosurvival function by acting as both a reactive oxygen species scavenger and BCL-XL activator.
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spelling pubmed-49053452016-06-15 CHCHD2 connects mitochondrial metabolism to apoptosis Liu, Yong Zhang, Yanping Mol Cell Oncol Author's Views As the powerhouse of cells and gatekeeper for apoptosis, mitochondria control life and death. CHCHD2, a mitochondrial protein previously known to regulate metabolism, has recently been identified as an apoptosis inhibitor. New data suggest a model in which CHCHD2 performs a prosurvival function by acting as both a reactive oxygen species scavenger and BCL-XL activator. Taylor & Francis 2015-05-05 /pmc/articles/PMC4905345/ /pubmed/27308501 http://dx.doi.org/10.1080/23723556.2015.1004964 Text en © 2015 The Author(s). Published with license by Taylor & Francis Group, LLC http://creativecommons.org/licenses/by-nc/3.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution-Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/), which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. The moral rights of the named author(s) have been asserted.
spellingShingle Author's Views
Liu, Yong
Zhang, Yanping
CHCHD2 connects mitochondrial metabolism to apoptosis
title CHCHD2 connects mitochondrial metabolism to apoptosis
title_full CHCHD2 connects mitochondrial metabolism to apoptosis
title_fullStr CHCHD2 connects mitochondrial metabolism to apoptosis
title_full_unstemmed CHCHD2 connects mitochondrial metabolism to apoptosis
title_short CHCHD2 connects mitochondrial metabolism to apoptosis
title_sort chchd2 connects mitochondrial metabolism to apoptosis
topic Author's Views
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4905345/
https://www.ncbi.nlm.nih.gov/pubmed/27308501
http://dx.doi.org/10.1080/23723556.2015.1004964
work_keys_str_mv AT liuyong chchd2connectsmitochondrialmetabolismtoapoptosis
AT zhangyanping chchd2connectsmitochondrialmetabolismtoapoptosis

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